Yang Pei-rong, Guo Shu-xia, Tan Xiao-hua, Yang Lei
Baoji Center for Disease Control and Prevention, Baoji 721006, China.
Zhonghua Yu Fang Yi Xue Za Zhi. 2009 Nov;43(11):960-4.
To research the co-infections of HIV and human herpesvirus 8 (HHV8) in Uygur high-risk groups of HIV infection in a city Xinjiang.
All 468 Uygurs at high HIV risk registered in the sentinel monitoring system in 2006 were enrolled in this study. The antibodies to HHV8 latency-associated nuclear antigens 1 (LANA1), lytic antigens open reading frame 65 (ORF65) and K8.1 were measured by enzyme linked immunosorbent assay (ELISA). Chi-square test and non-condition Logistic regression model were used for data analysis.
Of 468 sera samples, 67 (14.3%) were HIV and HHV8 co-infection positive.Male's HIV and HHV8 co-infection rate (22.6%, 54/239) was higher than the female's (5.7%, 13/229) (chi(2) = 27.285, P < 0.001). For those above 24 year old, HIV and HHV8 co-infection rate (15.8%, 65/412) was higher than the < 24 year old group's (3.6%, 2/56) (chi(2) = 5.987, P = 0.014). The group of Elementary school and illiterate people's HIV and HHV8 co-infection rate (20.7%, 40/193) was higher than the junior middle school and the above culture (9.8%, 27/275) (chi(2) = 10.999, P = 0.001). For the unmarried people, the co-infecting rate of HIV and HHV8 for the married, the cohabitants, the divorced or the widowers were 16.9% (14/83), 12.2% (42/345), 27.5% (11/40) respectively. There was significantly statistical difference among three marital status (chi(2) = 7.399, P = 0.025). Injecting drug users' HIV and HHV8 co-infection rate (26.5%, 50/189) was higher than non-injecting drug users' (6.1%, 17/279) (chi(2) = 38.083, P < 0.001), and stratified by gender, OR(M-H) was 4.207 (95%CI: 1.529 - 11.578). Via non-condition logistic stepwise regression analysis, only injecting drug use entered model, compared with non-injecting drug users, injecting drug users were more dangerous for HIV and HHV8 co-infecting (OR = 5.544; 95%CI: 3.081 - 9.975).
The HIV and HHV8 co-infection rate was higher in the Uygurs at high HIV risk in Xinjiang. Injecting drug use is a risk factor of the HIV and HHV8 co-infection, which might be one of routes of HIV and HHV8 co-infection among this group.
研究新疆某城市维吾尔族HIV感染高危人群中HIV与人类疱疹病毒8型（HHV8）的合并感染情况。
选取2006年哨点监测系统登记的468名维吾尔族HIV高危人群纳入本研究。采用酶联免疫吸附试验（ELISA）检测HHV8潜伏相关核抗原1（LANA1）、裂解抗原开放阅读框65（ORF65）和K8.1抗体。数据分析采用卡方检验和非条件Logistic回归模型。
468份血清样本中，67份（14.3%）HIV与HHV8合并感染阳性。男性HIV与HHV8合并感染率（22.6%，54/239）高于女性（5.7%，13/229）（χ² = 27.285，P < 0.001）。24岁及以上人群HIV与HHV8合并感染率（15.8%，65/412）高于24岁以下组（3.6%，2/56）（χ² = 5.987，P = 0.014）。小学及文盲人群HIV与HHV8合并感染率（20.7%，40/193）高于初中及以上文化程度人群（9.8%，27/275）（χ² = 10.999，P = 0.001）。未婚、已婚、同居、离异或丧偶人群HIV与HHV8合并感染率分别为16.9%（14/83）、12.2%（42/345）、27.5%（11/40）。三种婚姻状况间差异有统计学意义（χ² = 7.399，P = 0.025）。注射吸毒者HIV与HHV8合并感染率（26.5%，50/189）高于非注射吸毒者（6.1%，17/279）（χ² = 38.083，P < 0.001），按性别分层，OR（M-H）为4.207（95%CI：1.529 - 11.578）。经非条件Logistic逐步回归分析，仅注射吸毒进入模型，与非注射吸毒者相比，注射吸毒者发生HIV与HHV8合并感染的危险性更高（OR = 5.544；95%CI：3.081 - 9.975）。
新疆维吾尔族HIV高危人群中HIV与HHV8合并感染率较高。注射吸毒是HIV与HHV8合并感染的危险因素，可能是该人群中HIV与HHV8合并感染的途径之一。
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