Zhang Liang, Wu Pei-hong, Fan Wei-jun, Zhang Fu-jun, Huang Jin-hua, Tang Tian, Li Xin
Department of Imaging and Interventional Radiology, State Key Laboratory of Oncology in Southern China, Department of Medical Imaging and Interventional Radiology, Cancer Center, Sun Yat-sen University, Guangzhou 510060, China.
Zhonghua Yi Xue Za Zhi. 2009 Oct 13;89(37):2654-7.
To evaluate the conformablity and quantization controllability of multi-cluster conformable radiofrequency ablation electrode by ex vivo animal experiment.
The subject using in this experiment were fresh ex vivo ox liver. The electrode we used were the series of WHK-3 (including WHK-3 I and II), which were design and made by Welfare Electronic Technological Company (Beijing). Each electrode had 6 sub-electrode on opposite side (A and B). Both A and B side could separately in different length and radian so to form asymmetric shape. The difference between WHK-3 I and II were the shaft of I are electric conductive while it of WHK-3 II were inconductive by coating with insulant material. Our subject were divide into 3 group. In group 1 we do radiofrequency ablation in ex vivo ox liver with both sub-electrode (WHK-3 I and II) fully spread out symmetrically, then the diameter of 3D cross section in zone of melt necrosis between type I and II were compared. In group 2 we do radiofrequency ablation in ex vivo ox liver with WHK-3 I while the two side of sub-electrode were spread out asymmetrically in different shapes. Then the diameter of cross section which were parallel to the electrode shaft in zone of melt necrosis in different sub-electrode shape were compared. In group 3 we do the test same way as in group 2 on WHK-3 II electrode.
In group 1, there had no significant different between the diameter of melt necrosis zone in ex vivo ox liver with WHK-3 I and II (average around 6 x 6 x 3 cm(3)) while sub-electrodes were fully spread out symmetrically. In group 2, while sub-electrode in A side were fully spread and sub-electrode in B side were half spread, WHK-3 I electrode could form an asymmetric melt necrosis zone. The diameter on A side were 3.24 + or - 0.32 cm and it on B side were 1.87 + or - 0.24 cm. While only A side sub-electrode were spread out, the diameter on A side were nearly the same and it on B side were decreased to 1.55 + or - 0.16 cm. In group 3, while sub-electrode in A side were fully spread and sub-electrode in B side were half spread, WHK-3 II electrode could form an asymmetric melt necrosis zone too. The diameter on A side were 3.27 + or - 0.35 cm and it on B side were 1.65 + or - 0.23 cm. While only A side sub-electrode were spread out, the diameter on A side were nearly the same and it on B side were decreased even to 0.90 + or - 0.18 cm.
The series of WHK-3 could form an asymmetric melt necrosis zone in ex vivo tissue, which were more suitable to clinical usage. And both of them had quantization controllability, especially in WHK-3 II.
通过离体动物实验评估多簇适形射频消融电极的适形性和量化可控性。
本实验所用对象为新鲜离体牛肝。我们使用的电极是由北京福利电子技术公司设计制造的WHK - 3系列（包括WHK - 3 I和II）。每个电极在相对两侧（A和B）有6个分支电极。A和B侧可分别呈不同长度和弧度，从而形成不对称形状。WHK - 3 I和II的区别在于，WHK - 3 I的杆部导电，而WHK - 3 II的杆部通过涂覆绝缘材料不导电。我们的研究对象分为3组。在第1组中，我们在离体牛肝中对两个分支电极（WHK - 3 I和II）均完全对称展开的情况下进行射频消融，然后比较I型和II型之间融化坏死区域的三维横截面直径。在第2组中，我们在离体牛肝中对WHK - 3 I进行射频消融，同时分支电极的两侧以不同形状不对称展开。然后比较不同分支电极形状下融化坏死区域中与电极杆平行的横截面直径。在第3组中，我们对WHK - 3 II电极采用与第组相同的方式进行测试。
在第1组中，当分支电极完全对称展开时，离体牛肝中使用WHK - 3 I和II的融化坏死区域直径无显著差异（平均约为6×6×3 cm³）。在第2组中，当A侧分支电极完全展开而B侧分支电极半展开时，WHK - 3 I电极可形成不对称融化坏死区域。A侧直径为3.24±0.32 cm，B侧为1.87±0.24 cm。当仅A侧分支电极展开时，A侧直径基本相同，B侧直径降至1.55±0.16 cm。在第3组中，当A侧分支电极完全展开而B侧分支电极半展开时，WHK - 3 II电极也可形成不对称融化坏死区域。A侧直径为3.27±0.35 cm，B侧为1.65±0.23 cm。当仅A侧分支电极展开时，A侧直径基本相同，B侧直径甚至降至0.90±0.18 cm。
WHK - 3系列可在离体组织中形成不对称融化坏死区域，更适合临床应用。且两者均具有量化可控性，尤其是WHK - 3 II。
