Witt Constanze, Krengel Sven
University Hospital, Lübeck, Schleswig-Holstein, Germany.
Dermatol Online J. 2010 Jan 15;16(1):1.
The term "melanocytic nevus" comprises a group of clinically and pathologically distinct subtypes. In this prospective clinical study we evaluated the frequency, localization, and age and gender distribution of flat nevi (FN), Miescher nevi (MN), and Unna nevi (UN) in a caucasian population. Nevi were counted in 400 patients, of which 47 had a history of melanoma. Additionally, the patients answered to a detailed UV questionnaire. Flat nevi represented the most common type of melanocytic nevi, with a peak in the 3rd decade of life. They were mostly found on the extremities and on the trunk. Miescher nevi were most common in the 6th decade and were predominantly found in the head and neck region. Unna nevi showed a maximum in the 8th decade and they were mainly situated on the trunk. The counts of all three nevus subtypes were elevated in the melanoma group. Our results confirm that FN, MN, and UN represent melanocytic nevi with distinctive morphological and clinical characteristics. The role of sunlight seems to be more prominent in the pathogenesis of FN. The precise description of FN, MN, and UN may serve as a base for a pathogenetic distinction of subtypes of melanocytic nevi in the future.
术语“黑素细胞痣”包括一组临床和病理上不同的亚型。在这项前瞻性临床研究中，我们评估了白种人群中扁平痣（FN）、米舍尔痣（MN）和温纳痣（UN）的发生率、定位以及年龄和性别分布。对400名患者的痣进行了计数，其中47人有黑色素瘤病史。此外，患者还回答了一份详细的紫外线问卷。扁平痣是黑素细胞痣最常见的类型，在生命的第三个十年达到高峰。它们大多位于四肢和躯干。米舍尔痣在第六个十年最常见，主要见于头颈部区域。温纳痣在第八个十年达到最多，主要位于躯干。黑色素瘤组中所有三种痣亚型的计数均升高。我们的结果证实，FN、MN和UN代表具有独特形态和临床特征的黑素细胞痣。阳光在FN的发病机制中似乎作用更为突出。对FN、MN和UN的精确描述可能为未来黑素细胞痣亚型的病因学区分奠定基础。
