Department of Chemistry, Bahauddin Zakariya University, Multan, Pakistan.
J Enzyme Inhib Med Chem. 2010 Oct;25(5):737-49. doi: 10.3109/14756360903389906.
Triazole derived Schiff bases and their metal complexes (cobalt(II), copper(II), nickel(II), and zinc(II)) have been prepared and characterized using IR, (1)H and (13)C NMR, mass spectrometry, magnetic susceptibility and conductivity measurements, and CHN analysis data. The structure of L(2), N-[(5-methylthiophen-2-yl)methylidene]-1H-1,2,4-triazol-3-amine, has also been determined by the X-ray diffraction method. All the metal(II) complexes showed octahedral geometry except the copper(II) complexes, which showed distorted octahedral geometry. The triazole ligands and their metal complexes have been screened for their in vitro antibacterial, antifungal, and cytotoxic activity. All the synthesized compounds showed moderate to significant antibacterial activity against one or more bacterial strains. It is revealed that all the synthesized complexes showed better activity than the ligands, due to coordination.
三唑衍生的席夫碱及其金属配合物（钴（II）、铜（II）、镍（II）和锌（II））已经通过红外光谱（IR）、（1）H 和（13）C 核磁共振、质谱、磁化率和电导率测量以及 CHN 分析数据进行了制备和表征。L(2)，N-[(5-甲基噻吩-2-基)亚甲基]-1H-1,2,4-三唑-3-胺的结构也通过 X 射线衍射法确定。除了铜（II）配合物呈现扭曲的八面体几何形状外，所有的金属（II）配合物都呈现八面体几何形状。三唑配体及其金属配合物已被筛选用于体外抗菌、抗真菌和细胞毒性活性。所有合成的化合物对一种或多种细菌菌株均显示出中等至显著的抗菌活性。由于配位，所有合成的配合物都显示出比配体更好的活性。
