Murata Y, Miyamoto E, Ueda M
School of Pharmacy, Hokuriku University, Kanazawa, Japan.
J Pharm Sci. 1991 Jan;80(1):26-8. doi: 10.1002/jps.2600800107.
Five N'-alkyl-N-(2-aminoethyl)piperidines were synthesized and their in vitro antimicrobial activities were tested against four micro-organisms related to dental caries (Streptococcus mutans, S. sobrinus, Actinomyces viscosus, and A. naeslundii) which are known to be implicated in dental caries. The tetradecyl and hexadecyl derivatives possessed good bacteriostatic activity. Some derivatives exhibited a rapid bactericidal effect against S. mutans and S. sobrinus in aqueous solution. These compounds also possessed surfactant properties and anti-plaque activity.
合成了五种N'-烷基-N-(2-氨基乙基)哌啶，并测试了它们对四种与龋齿相关的微生物（变形链球菌、远缘链球菌、粘性放线菌和内氏放线菌）的体外抗菌活性，这些微生物已知与龋齿有关。十四烷基和十六烷基衍生物具有良好的抑菌活性。一些衍生物在水溶液中对变形链球菌和远缘链球菌表现出快速杀菌作用。这些化合物还具有表面活性剂性质和抗牙菌斑活性。
