Tanzer J M, Slee A M, Kamay B, Scheer E R
Antimicrob Agents Chemother. 1977 Jul;12(1):107-13. doi: 10.1128/AAC.12.1.107.
The antibacterial activity of three iodine-containing compounds was determined for strains of four dental plaque-forming microorganisms, using an in vitro preclinical plaque model system. Solutions of inorganic iodine, povidone-iodine, and Wescodyne were tested for antiplaque activity against preformed plaques of a number of strains of Streptococcus mutans, Streptococcus sanguis, Actinomyces viscosus, and Actinomyces naeslundii. Solutions of inorganic iodine were more effective as antiplaque agents, with respect to minimal bactericidal concentration and time and frequency of treatments, than solutions of Wescodyne and povidone-iodine. Inorganic iodine appeared to be particularly effective against the most cariogenic (S. mutans) and periodontopathic (A. viscosus) organisms while allowing survival of the least orally pathogenic plaque-forming microorganism (S. sanguis). It is suggested that topical application of solutions of inorganic iodine may be useful in controlling dental caries and actinomyces-associated periodontal disease.
使用体外临床前菌斑模型系统，测定了三种含碘化合物对四种形成牙菌斑的微生物菌株的抗菌活性。测试了无机碘溶液、聚维酮碘溶液和洗必泰葡萄糖酸盐溶液对多种变形链球菌、血链球菌、粘性放线菌和内氏放线菌菌株预先形成的菌斑的抗菌斑活性。就最小杀菌浓度以及处理时间和频率而言，无机碘溶液作为抗菌斑剂比洗必泰葡萄糖酸盐溶液和聚维酮碘溶液更有效。无机碘似乎对最具致龋性的（变形链球菌）和牙周病性的（粘性放线菌）微生物特别有效，同时能使口腔致病性最低的牙菌斑形成微生物（血链球菌）存活。有人提出，局部应用无机碘溶液可能有助于控制龋齿和与放线菌相关的牙周疾病。
