Soisson Emilie T, Hoban Peter W, Kammeyer Thomas, Kapatoes Jeffrey M, Westerly David C, Basavatia Amar, Tomé Wolfgang A
Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA.
Med Dosim. 2011 Spring;36(1):46-56. doi: 10.1016/j.meddos.2009.11.003.
The purpose of this study was to develop an efficient and effective planning technique for stereotactic radiosurgery using helical tomotherapy. Planning CTs and contours of 20 patients, previously treated in our clinic for brain metastases with linac-based radiosurgery using circular collimators, were used to develop a robust TomoTherapy planning technique. Plan calculation times as well as delivery times were recorded for all patients to allow for an efficiency evaluation. In addition, conformation and homogeneity indices were calculated as metrics to compare plan quality with that which is achieved with conventional radiosurgery delivery systems. A robust and efficient planning technique was identified to produce plans of radiosurgical quality using the TomoTherapy treatment planning system. Dose calculation did not exceed a few hours and resulting delivery times were less than 1 hour, which allows the process to fit into a single day radiosurgery workflow. Plan conformity compared favorably with published results for gamma knife radiosurgery. In addition, plan homogeneity was similar to linac-based approaches. The TomoTherapy planning software can be used to create plans of acceptable quality for stereotactic radiosurgery in a time that is appropriate for a radiosurgery workflow that requires that planning and delivery occur within 1 treatment day.
本研究的目的是开发一种使用螺旋断层放射治疗进行立体定向放射外科的高效规划技术。使用20例此前在我们诊所接受基于直线加速器的圆形准直器放射外科治疗脑转移瘤的患者的规划CT和轮廓，来开发一种可靠的断层放射治疗规划技术。记录所有患者的计划计算时间以及治疗时间，以便进行效率评估。此外，计算适形度和均匀性指数作为指标，将计划质量与传统放射外科治疗系统所达到的质量进行比较。确定了一种可靠且高效的规划技术，可使用断层放射治疗治疗计划系统生成放射外科质量的计划。剂量计算不超过数小时，且治疗时间少于1小时，这使得该流程能够适应单日放射外科工作流程。计划适形度与伽马刀放射外科的已发表结果相比具有优势。此外，计划均匀性与基于直线加速器的方法相似。断层放射治疗计划软件可用于在适合放射外科工作流程的时间内创建质量可接受的立体定向放射外科计划，该工作流程要求规划和治疗在1个治疗日内完成。
