Department of Bioinformatics, College of Life Sciences, Zhejiang University, Hangzhou 310058, PR China.
Biochem Biophys Res Commun. 2010 Mar 12;393(3):345-9. doi: 10.1016/j.bbrc.2010.01.129. Epub 2010 Feb 6.
MicroRNA (miRNA), recently recognized as a critical post-transcriptional modulator of gene expression, is involved in numerous biological processes in both animals and plants. Although eudicots and monocots, such as the model plants Arabidopsis (Arabidopsis thaliana) and rice (Oryza sativa), possess distinct root systems, several homologous miRNA families are reported to be involved in root growth control in both plants. Consistent with recent notion that numerous signaling pathways are implicated in root development, these miRNAs are implicated in auxin signaling, nutrition metabolism, or stress response and have potential role in mediating the signal interactions. However, a recapitulative representation of these results is especially desired. This review provides a global view of the involvement of miRNAs in root development focusing on the two plants, Arabidopsis and rice. Based on current research advances, several innovative mechanisms of miRNA transcription, feedback regulatory circuit between miRNAs and transcription factors (TFs), and miRNA-mediated signal interactions are also discussed.
MicroRNA (miRNA)，最近被认为是基因表达的关键转录后调控因子，参与动植物的许多生物学过程。尽管双子叶植物和单子叶植物（如模式植物拟南芥（Arabidopsis thaliana）和水稻（Oryza sativa））具有不同的根系，但据报道，几个同源的 miRNA 家族参与了这两种植物的根生长调控。最近的观点认为，许多信号通路参与根的发育，这些 miRNA 参与生长素信号、营养代谢或应激反应，并在介导信号相互作用中具有潜在作用。然而，特别需要对这些结果进行综述。本综述提供了 miRNA 参与根发育的全局视图，重点关注拟南芥和水稻这两种植物。基于当前的研究进展，还讨论了 miRNA 转录的几种创新机制、miRNA 与转录因子 (TF) 之间的反馈调节回路以及 miRNA 介导的信号相互作用。
