State Key Laboratory of Pulp and Paper Engineering, College of Light Industry and Food Sciences, South China University of Technology, Guangzhou 510640, China.
Biotechnol Adv. 2010 May-Jun;28(3):348-66. doi: 10.1016/j.biotechadv.2010.01.006. Epub 2010 Feb 6.
Nucleoside derivatives are a class of compounds that have attracted intense interest in biotechnology and medicine. Use of biocatalysts opens exciting opportunities for selective synthesis of many nucleoside derivatives, and such an approach offers simplicity, exquisite selectivity and environmentally benign processes. Here we reviewed current achievements in the biocatalytic transformation of nucleoside derivatives from the literature between 2000 and 2009. This article is arranged according to the types of reactions that can be employed to transform nucleoside derivatives, which include acylation, deacylation, glycosylation, halogenation and deamination.
核苷衍生物是一类在生物技术和医学领域引起强烈关注的化合物。生物催化剂的使用为许多核苷衍生物的选择性合成开辟了令人兴奋的机会，这种方法具有简单、高度选择性和环境友好的特点。在这里，我们回顾了 2000 年至 2009 年文献中核苷衍生物的生物催化转化的最新成果。本文根据可用于转化核苷衍生物的反应类型进行编排，包括酰化、脱酰化、糖基化、卤化和脱氨。
