牙齿缺失、载脂蛋白 E 与延迟词语回忆能力下降。
Tooth loss, apolipoprotein E, and decline in delayed word recall.
机构信息
Department of Anatomy and Neurobiology, College of Medicine, MN 210 Chandler Medical Center, University of Kentucky, Lexington, KY 40536, USA.
出版信息
J Dent Res. 2010 May;89(5):473-7. doi: 10.1177/0022034509357881. Epub 2010 Feb 5.
Our previous research suggests an association between a low number of teeth and increased risk of dementia. The aim of the present study was to determine if a low number of teeth is specifically related to memory decline as evidenced by low Delayed Word Recall scores. In addition, we examined the combined effect of a low number of teeth and the apolipoprotein E epsilon4 allele on Delayed Word Recall scores. We hypothesized that the scores of those who had the allele and a low number of teeth (0-9) would decline more rapidly over time than those participants with a greater number of teeth who lacked the allele. We found that individuals with both risk factors (the allele and fewer teeth) had lower Delayed Word Recall scores at the first examination and declined more quickly compared with participants with neither of these risk factors or with either risk factor alone.
我们之前的研究表明，牙齿数量少与痴呆风险增加之间存在关联。本研究的目的是确定牙齿数量少是否与记忆力下降有关，具体表现为延迟单词回忆测试得分较低。此外，我们还研究了牙齿数量少和载脂蛋白 E ε4 等位基因的综合影响对延迟单词回忆测试得分的影响。我们假设，携带该等位基因且牙齿数量较少（0-9）的个体的分数在一段时间内的下降速度会比那些牙齿数量较多且不携带该等位基因的参与者更快。我们发现，同时具有这两个风险因素（等位基因和较少的牙齿）的个体在第一次检查时的延迟单词回忆测试得分较低，并且与不具有这两个风险因素或只有一个风险因素的参与者相比，下降速度更快。
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