修女研究中的牙齿脱落、痴呆与神经病理学
Tooth loss, dementia and neuropathology in the Nun study.
作者信息
Stein Pamela Sparks, Desrosiers Mark, Donegan Sara Jean, Yepes Juan F, Kryscio Richard J
机构信息
Department of Anatomy and Neurobiology, College of Medicine, MN 210 Chandler Medical Center, University of Kentucky, Lexington, KY 40536, USA.
出版信息
J Am Dent Assoc. 2007 Oct;138(10):1314-22; quiz 1381-2. doi: 10.14219/jada.archive.2007.0046.
BACKGROUND
Numerous studies have linked dementia to the subsequent deterioration of oral health. Few investigators, however, have examined oral disease as a potential risk factor in the development of dementia. The authors conducted a study to investigate a potential association between a history of oral disease and the development of dementia.
METHODS
Longitudinal dental records supplemented data collected from 10 annual cognitive assessments of 144 Milwaukee participants in the Nun Study, a longitudinal study of aging and Alzheimer disease, who were 75 to 98 years old. Neuropathologic findings at autopsy were available for 118 participants who died.
RESULTS
A low number of teeth increased the risk of higher prevalence and incidence of dementia.
CONCLUSION
Participants with the fewest teeth had the highest risk of prevalence and incidence of dementia.
CLINICAL IMPLICATIONS
Edentulism or very few (one to nine) teeth may be predictors of dementia late in life.
背景
众多研究已将痴呆与随后的口腔健康恶化联系起来。然而，很少有研究者将口腔疾病视为痴呆发展的潜在风险因素。作者开展了一项研究，以调查口腔疾病史与痴呆发展之间的潜在关联。
方法
纵向牙科记录补充了从144名参加修女研究的密尔沃基参与者的10次年度认知评估中收集的数据，该研究是一项关于衰老和阿尔茨海默病的纵向研究，参与者年龄在75至98岁之间。118名死亡参与者的尸检神经病理学结果可得。
结果
牙齿数量少会增加痴呆患病率和发病率升高的风险。
结论
牙齿最少的参与者患痴呆的患病率和发病率风险最高。
临床意义
无牙或牙齿极少（1至9颗）可能是晚年痴呆的预测指标。
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