McNally Melanie A, Crocetti Deana, Mahone E Mark, Denckla Martha B, Suskauer Stacy J, Mostofsky Stewart H
Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
J Child Neurol. 2010 Apr;25(4):453-62. doi: 10.1177/0883073809350221. Epub 2010 Feb 5.
Response control is impaired in attention-deficit hyperactivity disorder (ADHD). Given the corpus callosum's role in response control, we compared callosal morphology in 64 children with ADHD and 64 typically developing children, aged 7 to 13 years, and investigated the relationships between callosal morphology and response control. Area and circumference of 5 callosal segments (genu, rostral body, midbody, isthmus, and splenium) were normalized for cerebral volume and examined for correlation with mean reaction time, intrasubject variability, and/or commission error rate from a go/no-go task. There were no between-group differences in segment areas or circumferences. Reaction time correlated with midbody circumference for boys with ADHD and isthmus circumference for girls with ADHD. For the entire cohort, rostral body circumference correlated with intrasubject variability. Impaired response control in ADHD is associated with anomalies in frontal interhemispheric connections. Future studies examining callosal shape will illuminate the anatomic basis of correlations between callosal segment circumference and response control.
注意缺陷多动障碍（ADHD）患者的反应控制能力受损。鉴于胼胝体在反应控制中的作用，我们比较了64名7至13岁的ADHD儿童和64名发育正常儿童的胼胝体形态，并研究了胼胝体形态与反应控制之间的关系。对5个胼胝体节段（膝部、嘴侧体部、中部、峡部和压部）的面积和周长进行脑容量标准化，并检查其与去/不去任务中的平均反应时间、受试者内变异性和/或错误率的相关性。两组之间在节段面积或周长上没有差异。ADHD男孩的反应时间与中部周长相关，ADHD女孩的反应时间与峡部周长相关。对于整个队列，嘴侧体部周长与受试者内变异性相关。ADHD患者反应控制受损与额叶半球间连接异常有关。未来研究胼胝体形状将阐明胼胝体节段周长与反应控制之间相关性的解剖学基础。
