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斯努皮——一种用于研究生物分子网络的统一 Petri 网框架。

Snoopy--a unifying Petri net framework to investigate biomolecular networks.

机构信息

Magdeburg Centre for Systems Biology (MaCS), Otto von Guericke University, Max Planck Institute for Dynamics of Complex Technical Systems, Magdeburg, Germany.

出版信息

Bioinformatics. 2010 Apr 1;26(7):974-5. doi: 10.1093/bioinformatics/btq050. Epub 2010 Feb 7.

Abstract

SUMMARY

To investigate biomolecular networks, Snoopy provides a unifying Petri net framework comprising a family of related Petri net classes. Models can be hierarchically structured, allowing for the mastering of larger networks. To move easily between the qualitative, stochastic and continuous modelling paradigms, models can be converted into each other. We get models sharing structure, but specialized by their kinetic information. The analysis and iterative reverse engineering of biomolecular networks is supported by the simultaneous use of several Petri net classes, while the graphical user interface adapts dynamically to the active one. Built-in animation and simulation are complemented by exports to various analysis tools. Snoopy facilitates the addition of new Petri net classes thanks to its generic design.

AVAILABILITY

Our tool with Petri net samples is available free of charge for non-commercial use at http://www-dssz.informatik.tu-cottbus.de/snoopy.html; supported operating systems: Mac OS X, Windows and Linux (selected distributions).

摘要

摘要

为了研究生物分子网络,Snoopy 提供了一个统一的 Petri 网框架,包括一系列相关的 Petri 网类。模型可以分层结构,允许掌握更大的网络。为了在定性、随机和连续建模范例之间轻松转换,模型可以相互转换。我们得到了共享结构但通过其动力学信息专门化的模型。通过同时使用几种 Petri 网类来支持生物分子网络的分析和迭代反向工程,而图形用户界面则根据活动的 Petri 网类动态自适应。内置的动画和模拟功能通过导出到各种分析工具得到补充。Snoopy 由于其通用设计,方便了新的 Petri 网类的添加。

可用性

我们的工具带有 Petri 网样本,可免费用于非商业用途,请访问 http://www-dssz.informatik.tu-cottbus.de/snoopy.html;支持的操作系统:Mac OS X、Windows 和 Linux(选定的发行版)。

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