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纳米技术:在口腔生物膜中的作用

Nanotechnology: role in dental biofilms.

作者信息

Bhardwaj Sonia B, Mehta Manjula, Gauba K

机构信息

Department of Microbiology, Dr. H.S.J Institute of Dental Sciences and Hospital, Punjab University, Chandigarh, India.

出版信息

Indian J Dent Res. 2009 Oct-Dec;20(4):511-3. doi: 10.4103/0970-9290.59440.

Abstract

Biofilms are surface-adherent populations of microorganisms consisting of cells, water and extracellular matrix material Nanotechnology is promising field of science which can guide our understanding of the role of interspecies interaction in the development of biofilm. Streptococcus mutans with other species of bacteria has been known to form dental biofilm. The correlation between genetically modified bacteria Streptococcus mutans and nanoscale morphology has been assessed using AFMi.e atomic force microscopy. Nanotechnology application includes 16O/18O reverse proteolytic labeling,use of quantum dots for labeling of bacterial cells, selective removal of cariogenic bacteria while preserving the normal oral flora and silver antimicrobial nanotechnology against pathogens associated with biofilms. The future comprises a mouthwash full of smart nanomachines which can allow the harmless flora of mouth to flourish in a healthy ecosystem.

摘要

生物膜是由细胞、水和细胞外基质材料组成的微生物表面附着群体。纳米技术是一个很有前景的科学领域,它可以引导我们理解种间相互作用在生物膜形成中的作用。变形链球菌与其他细菌种类已知会形成牙菌斑生物膜。已使用原子力显微镜(AFM)评估了基因改造的变形链球菌与纳米级形态之间的相关性。纳米技术的应用包括16O/18O反向蛋白水解标记、使用量子点标记细菌细胞、在保留正常口腔菌群的同时选择性去除致龋细菌以及针对与生物膜相关病原体的银抗菌纳米技术。未来会有充满智能纳米机器的漱口水,它能让口腔中的无害菌群在健康的生态系统中蓬勃生长。

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