Martínez-Robles Ángel Manuel, Loyola-Rodríguez Juan Pablo, Zavala-Alonso Norma Verónica, Martinez-Martinez Rita Elizabeth, Ruiz Facundo, Lara-Castro René Homero, Donohué-Cornejo Alejandro, Reyes-López Simón Yobanny, Espinosa-Cristóbal León Francisco
Graduate Program in Orthodontics, Faculty of Dentistry, Mexicali Campus, Autonomous University of Baja California, Alvaro Obregon and Julian Carrillo Avenue, Nueva, 21100 Mexicali, Baja California, México.
Master Program in Advanced Dentistry, Faculty of Dentistry, Autonomous University of San Luis Potosi, Manuel Nava Avenue, Universitary Campus, 78290 San Luis Potosí, S. L. P., México.
Nanomaterials (Basel). 2016 Jul 22;6(7):136. doi: 10.3390/nano6070136.
(1) Background: () is the principal pathogen involved in the formation of dental caries. Other systemic diseases have also been associated with specific serotypes (, , , and ). Silver nanoparticles (SNP) have been demonstrated to have good antibacterial effects against ; therefore, limited studies have evaluated the antimicrobial activity of biofunctionalized SNP on serotypes. The purpose of this work was to prepare and characterize coated SNP using two different organic components and to evaluate the antimicrobial activity of SNP in clinical isolates of strains and serotypes; (2) Methods: SNP with bovine serum albumin (BSA) or chitosan (CS) coatings were prepared and the physical, chemical and microbiological properties of SNP were evaluated; (3) Results: Both types of coated SNP showed antimicrobial activity against bacteria and serotypes. Better inhibition was associated with smaller particles and BSA coatings; however, no significant differences were found between the different serotypes, indicating a similar sensitivity to the coated SNP; (4) Conclusion: This study concludes that BSA and CS coated SNP had good antimicrobial activity against strains and the four serotypes, and this study suggest the widespread use of SNP as an antimicrobial agent for the inhibition of bacteria.
(1) 背景：（某种细菌名称未给出）是参与龋齿形成的主要病原体。其他全身性疾病也与特定血清型（如，，，和）有关。银纳米颗粒（SNP）已被证明对（某种细菌名称未给出）具有良好的抗菌作用；因此，有限的研究评估了生物功能化SNP对血清型的抗菌活性。这项工作的目的是使用两种不同的有机成分制备并表征包覆的SNP，并评估SNP在（某种细菌名称未给出）菌株和血清型临床分离株中的抗菌活性；(2) 方法：制备了带有牛血清白蛋白（BSA）或壳聚糖（CS）涂层的SNP，并评估了SNP的物理、化学和微生物学性质；(3) 结果：两种类型的包覆SNP均对（某种细菌名称未给出）细菌和血清型显示出抗菌活性。更好的抑制作用与较小的颗粒和BSA涂层相关；然而，不同血清型之间未发现显著差异，表明对包覆SNP的敏感性相似；(4) 结论：本研究得出结论，BSA和CS包覆的SNP对（某种细菌名称未给出）菌株和四种血清型具有良好的抗菌活性，并且本研究建议广泛使用SNP作为抑制（某种细菌名称未给出）细菌的抗菌剂。
