Bouret Sebastien G
The Saban Research Institute, Neuroscience Program, Childrens Hospital Los Angeles, University of Southern California, Los Angeles, CA, USA.
Nestle Nutr Workshop Ser Pediatr Program. 2010;65:25-35; discussion 35-9. doi: 10.1159/000281143. Epub 2010 Feb 1.
A large body of epidemiological data suggests that adverse early environments, including obesity during pregnancy or early postnatal life, are linked to an elevated prevalence of metabolic disease in adult offspring. The mechanisms underlying these effects are still poorly understood, but recent data from rodents provide insight into a potential role for the brain in this 'metabolic programming.' This review summarizes the developmental changes that have been observed in the hypothalamus in response to changes in the early nutritional and hormonal environment. It also discusses how resetting a diverse array of neuroendocrine systems may have long-term effects on the regulation of metabolism and energy balance.
大量流行病学数据表明，不良的早期环境，包括孕期或出生后早期的肥胖，与成年后代代谢疾病患病率升高有关。这些影响背后的机制仍知之甚少，但来自啮齿动物的最新数据为大脑在这种“代谢编程”中的潜在作用提供了见解。本综述总结了下丘脑因早期营养和激素环境变化而发生的发育变化。它还讨论了重置一系列不同的神经内分泌系统如何可能对代谢和能量平衡的调节产生长期影响。
