Equipe Bases Moléculaires de la Progression des Cancers du Poumon, Centre de Recherche INSERM U823, Institut Albert Bonniot, Grenoble, France; Université Joseph Fourier, Grenoble, France.
Cell Adh Migr. 2010 Jan-Mar;4(1):114-23. doi: 10.4161/cam.4.1.10977. Epub 2010 Jan 16.
Cellular division is an ordered, tightly regulated process involving multiple checkpoints that assess extracellular growth signals, cell size and DNA integrity. Progression throughout the cell cycle is based on the activation of different CDK-cyclin complexes that prevent cells from entering into a new phase until thay have successfully complete the previous one. In addition, a series of cell cycle checkpoints are designed to preserve genome integrity and chromosomal stability. Neoplastic lung cells develop the ability to bypass several of these checkpoints, and tumor cell proliferation is frequently associated with genetic or epigenetic alterations in key regulators of the cell cycle. The goal of this review is to summarize the knowledge about the dysregulation of major cell cycle regulators in lung cancer pathogenesis and to discuss the use of these proteins as targets for therapeutic intervention.
细胞分裂是一个有序且受到严格调控的过程，涉及多个检查点，用于评估细胞外生长信号、细胞大小和 DNA 完整性。细胞周期的进展基于不同 CDK-cyclin 复合物的激活，这些复合物可防止细胞进入新的阶段，直到成功完成前一个阶段。此外，还设计了一系列细胞周期检查点来保护基因组完整性和染色体稳定性。肿瘤肺细胞具有绕过这些检查点的能力，而肿瘤细胞的增殖通常与细胞周期关键调节因子的遗传或表观遗传改变有关。本综述的目的是总结肺癌发病机制中主要细胞周期调节剂失调的知识，并讨论将这些蛋白作为治疗干预的靶点。
