肺癌中的导向分子。
Guidance molecules in lung cancer.
机构信息
Medical University of South Carolina, Division of Hematology/Oncology, Charleston, SC, USA.
出版信息
Cell Adh Migr. 2010 Jan-Mar;4(1):130-45. doi: 10.4161/cam.4.1.10882. Epub 2010 Jan 7.
Abstract
Guidance molecules were first described in the nervous system to control axon outgrowth direction. They are also widely expressed outside the nervous system where they control cell migration, tissue development and establishment of the vascular network. In addition, they are involved in cancer development, tumor angiogenesis and metastasis. This review is primarily focused on their functions in lung cancer and their involvement in lung development is also presented. Five guidance molecule families and their corresponding receptors are described, including the semaphorins/neuropilins/plexins, ephrins and Eph receptors, netrin/DCC/UNC5, Slit/Robo and Notch/Delta. In addition, the possibility to target these molecules as a therapeutic approach in cancer is discussed.
摘要
导向分子最初在神经系统中被描述为控制轴突生长方向。它们在神经系统外也广泛表达，在那里它们控制细胞迁移、组织发育和血管网络的建立。此外，它们还参与癌症的发展、肿瘤血管生成和转移。本综述主要集中在它们在肺癌中的功能，同时也介绍了它们在肺发育中的作用。描述了五个导向分子家族及其相应的受体，包括神经导向素/神经丛蛋白/多聚蛋白、 Eph 家族和 Eph 受体、 netrin/DCC/UNC5、 Slit/Robo 和 Notch/Delta。此外，还讨论了将这些分子作为癌症治疗方法的可能性。
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