Division of Nuclear Medicine, Department of Radiology, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USA.
Clin Nucl Med. 2009 Dec;34(12):891-3. doi: 10.1097/RLU.0b013e3181bed135.
We report the case of a 17-year-old girl who presented with a several month history of fevers and abdominal pain. After cytomegalovirus (CMV) and Epstein-Barr virus (EBV) titers returned normal, FDG-PET/CT was obtained due to concern for lymphoma. FDG-PET/CT revealed a pattern of hypermetabolic activity in the adenoids, bilateral cervical lymph nodes, abdominal lymph nodes, and spleen, highly concerning for lymphoma. However, subsequent biopsy of a cervical lymph node revealed lymphadenitis consistent with EBV. This case highlights infection as the most well-known false-positive cause on FDG-PET, and how biopsy is essential to definitively distinguish malignancy from infection.
我们报告了一例 17 岁女孩的病例，她因发热和腹痛就诊，病史已有数月。巨细胞病毒 (CMV) 和 EBV 滴度恢复正常后，由于担心淋巴瘤，进行了 FDG-PET/CT 检查。FDG-PET/CT 显示腺样体、双侧颈部淋巴结、腹部淋巴结和脾脏的代谢活性增高，强烈提示淋巴瘤。然而，随后对颈部淋巴结的活检显示符合 EBV 的淋巴结炎。本病例强调了感染是 FDG-PET 最常见的假阳性原因，以及活检对于明确区分恶性肿瘤和感染至关重要。
