免疫复合物性肾小球肾炎大鼠肾脏的胶原酶活性

Collagenase activity of rat kidney with immune complex glomerulonephritis.

作者信息

Lubec G, Ratzenhofer E

出版信息

Clin Chim Acta. 1978 Jan 2;82(1-2):205-7. doi: 10.1016/0009-8981(78)90046-3.

PMID:201399

Abstract

By means of a biological assay the collagenolytic activity of kidneys from rats with experimental immune complex glomerulonephritis and control animals was tested. We detected collagenolysis in both panels but found quantitative differences in the collagenase activity. The enzymatic collagenolysis was significantly increased (P less than 0.001) in the nephritic kidneys. From the fact that the chelating agent EDTA inhibited potentially the released enzyme it can be concluded that the origin is the polymorphonuclear granules.

摘要

通过生物测定法检测了实验性免疫复合物肾小球肾炎大鼠和对照动物肾脏的胶原olytic活性。我们在两组中均检测到胶原olysis，但发现胶原酶活性存在定量差异。肾炎肾脏中的酶促胶原olysis显著增加（P小于0.001）。从螯合剂EDTA可能抑制释放的酶这一事实可以得出结论，其来源是多形核颗粒。