TERC 附近的常见变异与端粒平均长度有关。
Common variants near TERC are associated with mean telomere length.
机构信息
Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Leicester, UK.
出版信息
Nat Genet. 2010 Mar;42(3):197-9. doi: 10.1038/ng.532. Epub 2010 Feb 7.
Abstract
We conducted genome-wide association analyses of mean leukocyte telomere length in 2,917 individuals, with follow-up replication in 9,492 individuals. We identified an association with telomere length on 3q26 (rs12696304, combined P = 3.72 x 10(-14)) at a locus that includes TERC, which encodes the telomerase RNA component. Each copy of the minor allele of rs12696304 was associated with an approximately 75-base-pair reduction in mean telomere length, equivalent to approximately 3.6 years of age-related telomere-length attrition.
摘要
我们对 2917 个人的白细胞端粒平均长度进行了全基因组关联分析，并在 9492 个人中进行了后续复制。我们在包含编码端粒酶 RNA 成分的 TERC 的 3q26 位置（rs12696304，合并 P = 3.72 x 10(-14)) 发现了与端粒长度的关联。rs12696304 的次要等位基因的每一个副本与平均端粒长度减少约 75 个碱基对有关，相当于大约 3.6 年与年龄相关的端粒长度损耗。
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