Department of Materials Science and Engineering, University of Michigan, Ann Arbor, MI 48109, USA.
Ann Biomed Eng. 2010 Jun;38(6):2013-31. doi: 10.1007/s10439-010-9937-1. Epub 2010 Feb 6.
This discussion and review article focuses on the possible use of regenerative techniques applied to the interfaces between skin and medical implants. As is widely known, the area of contact between an implant and the skin--the skin-implant interface--is prone to recurrent and persistent problems originated from the lack of integration between the material of the implant and the skin. Producing a long-term successful biointerface between skin and the implanted device is still an unsolved problem. These complications have prevented the development of advanced prosthetics and the evolution of biointegrated devices with new technologies. While previous techniques addressing these issues have relied mostly on the coating of the implants or the modification of the topology of the devices, recent in vitro developed techniques have shown that is possible to introduce biocompatible and possibly regenerative materials at the skin-device interface. These techniques have also shown that the process of delivering the materials has biological effects on the skin surrounding the implant, thus converting bioinert into bioactive, dynamic interfaces. Given that the best clinical outcome is the long-term stabilization and integration of the soft tissue around the implant, this article presents the basis for the selection of regenerative materials and therapies for long-term use at the skin-device interface, with focus on the use of natural biopolymers and skin cell transplantation.
这篇讨论和综述文章主要关注再生技术在皮肤和医疗植入物界面的可能应用。众所周知，植入物和皮肤之间的接触区域——皮肤-植入物界面——容易出现源于植入物材料和皮肤之间缺乏整合的反复和持续的问题。在皮肤和植入设备之间产生长期成功的生物界面仍然是一个未解决的问题。这些并发症阻碍了先进义肢的发展和具有新技术的生物整合设备的演进。虽然以前解决这些问题的技术主要依赖于植入物的涂层或设备拓扑结构的修改，但最近体外开发的技术表明，可以在皮肤-设备界面引入生物相容性和可能具有再生性的材料。这些技术还表明，输送材料的过程对植入物周围的皮肤具有生物学影响，从而将生物惰性转化为生物活性、动态界面。鉴于最佳临床结果是植入物周围软组织的长期稳定和整合，本文提出了在皮肤-设备界面选择长期使用的再生材料和疗法的基础，重点是使用天然生物聚合物和皮肤细胞移植。
