Department of Animal Science, Michigan State University, East Lansing, MI 48824, USA.
Folia Microbiol (Praha). 2009 Nov;54(6):521-6. doi: 10.1007/s12223-009-0075-9. Epub 2010 Feb 7.
Inhibition of methanogenesis in ruminal cultures was attempted by hindering thiamine availability through its degradation by 'polyphenols' and competition for active sites on enzymes and transporters using thiamine structural analogs. Effects on fermentation were small and not consistently reversed by adding thiamine. Lack of major effects of the compounds evaluated could be due to intracellular synthesis of thiamine covering most requirements.
通过“多酚”降解来抑制硫胺素的可用性，从而抑制瘤胃培养物中的甲烷生成，并使用硫胺素结构类似物竞争酶和转运体上的活性位点，试图达到这一目的。对发酵的影响很小，添加硫胺素也不能使其恢复。评估的化合物没有产生主要影响的原因可能是细胞内合成的硫胺素满足了大部分需求。
