Biochemistry Division, Central Drug Research Institute, Lucknow-226001, Uttar Pradesh, India.
Nat Prod Res. 2010 Feb;24(3):258-65. doi: 10.1080/14786410902836693.
The present report confirms the anti-hyperglycaemic and anti-dyslipidemic properties of 4-hydroxyisoleucine, an unusual amino acid isolated from Trigonella foenum-graecum seeds, for the first time in a well-characterised model of type II diabetes, i.e. db/db mice. 4-Hydroxyisoleucine, when given orally to these mice at 50 mg kg(-1) dose level, significantly (p < 0.05) declined their elevated blood glucose, plasma insulin, triglycerides, total cholesterol, low-density lipoprotein-cholesterol levels and raised their declined plasma high-density lipoprotein-cholesterol level. These results indicate that 4-hydroxyisoleucine exhibits significant potential as an anti-diabetic agent by suppressing progression of type II diabetic states that is suggested by enhancement of insulin sensitivity and glucose uptake in peripheral tissue.
本报告首次在 II 型糖尿病的典型模型，即 db/db 小鼠中证实了 4-羟基异亮氨酸（一种从甜三叶草种子中分离出的特殊氨基酸）的降血糖和降血脂作用。4-羟基异亮氨酸以 50mg/kg 的剂量口服给予这些小鼠时，可显著（p<0.05）降低其升高的血糖、血浆胰岛素、甘油三酯、总胆固醇、低密度脂蛋白胆固醇水平，并升高其降低的血浆高密度脂蛋白胆固醇水平。这些结果表明，4-羟基异亮氨酸通过增强外周组织的胰岛素敏感性和葡萄糖摄取来抑制 II 型糖尿病状态的进展，具有作为抗糖尿病药物的显著潜力。
