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基于人群的样本中按种族/民族划分的处方药总体暴露情况:来自波士顿地区社区健康调查的结果。

General exposures to prescription medications by race/ethnicity in a population-based sample: results from the Boston Area Community Health Survey.

机构信息

New England Research Institutes, Watertown, MA 02472, USA.

出版信息

Pharmacoepidemiol Drug Saf. 2010 Apr;19(4):384-92. doi: 10.1002/pds.1920.

Abstract

PURPOSE

Few recent U.S. studies have examined population-based patterns in prescription drug use and even fewer have considered detailed patterns by race/ethnicity. In a representative community sample, our objectives were to determine the most commonly used prescription drug classes, and to describe their use by age, gender, and race/ethnicity.

METHODS

Cross-sectional epidemiologic study of 5503 (1767 black, 1877 Hispanic, 1859 white) community-dwelling participants aged 30-79 in the Boston Area Community Health (BACH) Survey (2002-2005). Using medication information collected from an in-home interview and medication inventory, the prevalence of use of a therapeutic class (95% confidence interval (95%CI)) in the past month was estimated by gender, age group, and race/ethnicity. Estimates were weighted inversely to the probability of sampling for generalizablity to Boston, MA.

RESULTS

The therapeutic class containing selective serotonin reuptake inhibitor/serotonin norepinephrine reuptake inhibitor (SSRI/SNRI) antidepressants was most commonly used (14.6%), followed by statins (13.9%), beta-adrenergic blockers (10.6%), and angiotensin-converting enzyme (ACE) inhibitors (10.5%). Within all age groups and both genders, black participants were substantially less likely than white to use SSRI/SNRI antidepressants (e.g., black men: 6.0% [95%CI: 3.9-8.1%]; white men: 15.0% [95%CI: 10.2-19.4%]). Other race/ethnic differences were observed: for example, black women were significantly less likely than other groups to use benzodiazepines (e.g., black: 2.6% [95%CI: 1.2-3.9%]; Hispanic: 9.4% [95%CI: 5.8-13.0%]).

CONCLUSIONS

Race/ethnic differences in use of prescription therapeutic classes were observed in our community sample. Examining therapeutic classes rather than individual drugs resulted in a different distribution of common exposures compared to other surveys.

摘要

目的

近期美国的研究很少涉及基于人群的处方药物使用模式,且很少考虑按种族/民族详细分类的模式。在一个具有代表性的社区样本中,我们的目标是确定最常用的处方药物类别,并按年龄、性别和种族/民族描述其使用情况。

方法

这是一项横断面流行病学研究,纳入了 5503 名(1767 名黑人、1877 名西班牙裔、1859 名白人)年龄在 30-79 岁的居住在社区的参与者,他们来自波士顿地区社区健康调查(BACH)(2002-2005 年)。利用在家中访谈和药物清单中收集的药物信息,按性别、年龄组和种族/民族估计过去一个月内使用治疗类别(95%置信区间(95%CI))的流行率。估计结果按抽样概率进行反向加权,以实现对马萨诸塞州波士顿的推广。

结果

含有选择性 5-羟色胺再摄取抑制剂/5-羟色胺去甲肾上腺素再摄取抑制剂(SSRI/SNRI)抗抑郁药的治疗类别是最常用的(14.6%),其次是他汀类药物(13.9%)、β肾上腺素能阻滞剂(10.6%)和血管紧张素转换酶(ACE)抑制剂(10.5%)。在所有年龄组和性别中,与白人相比,黑人参与者使用 SSRI/SNRI 抗抑郁药的可能性要小得多(例如,黑人男性:6.0%[95%CI:3.9-8.1%];白人男性:15.0%[95%CI:10.2-19.4%])。还观察到其他种族/民族差异:例如,黑人女性使用苯二氮䓬类药物的可能性明显低于其他组(例如,黑人:2.6%[95%CI:1.2-3.9%];西班牙裔:9.4%[95%CI:5.8-13.0%])。

结论

在我们的社区样本中观察到了处方治疗类别使用方面的种族/民族差异。与其他调查相比,检查治疗类别而不是单一药物会导致常见暴露的分布不同。

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