母亲产前使用对乙酰氨基酚与胎儿生长的比较。
Comparison of fetal growth by maternal prenatal acetaminophen use.
机构信息
Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD, USA.
Department of Environmental Health, Rollins School of public Health, Emory University, Atlanta, GA, USA.
出版信息
Pediatr Res. 2019 Aug;86(2):261-268. doi: 10.1038/s41390-019-0379-7. Epub 2019 Mar 25.
BACKGROUND
Equivocal findings exist regarding prenatal acetaminophen use and various adverse neonatal and childhood health outcomes, though with no data on fetal growth. We evaluated whether fetal growth differed by maternal acetaminophen use.
METHODS
Racially diverse, healthy women with low-risk antenatal profiles from 12 US clinical centers were enrolled in a prospective cohort study and followed until delivery. Ultrasound measurements of fetal parameters and self-reported prenatal acetaminophen use were collected at enrollment and up to five follow-up visits. Prenatal acetaminophen use was dichotomized as none or any.
RESULTS
Among 2291 women, 932 (41%) reported the use of acetaminophen medications during the current pregnancy. Estimated growth curves of fetal parameters did not differ between women reporting use of any medication containing acetaminophen and women with no reported use of the same.
CONCLUSION
Among healthy mothers with low-risk pregnancies, maternal acetaminophen use was not associated with alterations in fetal growth.
背景
尽管关于产前使用对乙酰氨基酚与各种新生儿和儿童健康不良结局之间的关系存在不确定的研究结果，但目前尚无关于胎儿生长的相关数据。我们评估了母亲使用对乙酰氨基酚是否会导致胎儿生长的差异。
方法
来自美国 12 个临床中心的具有低风险产前特征的不同种族的健康孕妇被纳入一项前瞻性队列研究，并随访至分娩。在入组时和最多五次随访时收集胎儿参数的超声测量值和自我报告的产前对乙酰氨基酚使用情况。将产前对乙酰氨基酚使用情况分为无或有。
结果
在 2291 名女性中，有 932 名（41%）报告在当前妊娠期间使用过含对乙酰氨基酚的药物。报告使用任何含有对乙酰氨基酚的药物的女性与未报告使用相同药物的女性的胎儿参数生长曲线没有差异。
结论
在具有低风险妊娠的健康母亲中，母亲使用对乙酰氨基酚与胎儿生长的改变无关。
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