Swiss Federal Institute of Technology (ETH) Zürich, HCI H405, Switzerland.
Org Lett. 2010 Mar 5;12(5):1120-3. doi: 10.1021/ol100123p.
The stereoselective synthesis of the monocyclic peloruside A analogue 4 has been achieved, following a new efficient approach for the introduction of the side chain, involving a late-stage addition of vinyl lithium species 7a to aldehyde 8. Further key steps are a highly diastereoselective allyltitanation reaction and a RCM-based macrocyclization.
已经实现了单环佩罗鲁索德 A 类似物 4 的立体选择性合成，采用了一种新的有效方法引入侧链，涉及烯丙基锂物种 7a 对醛 8 的后期加成。进一步的关键步骤是高度非对映选择性的烯丙基钛化反应和基于 RCM 的大环化反应。
