快速获得（+）-peloruside A 的构象类似物。
Rapid access to conformational analogues of (+)-peloruside A.
机构信息
Department of Chemistry and Biochemistry and the Mike and Josie Harper Cancer Research Institute, University of Notre Dame, 251 Nieuwland Science Hall, Notre Dame, Indiana 46556-5670, USA.
出版信息
Org Lett. 2012 Feb 3;14(3):669-71. doi: 10.1021/ol203268t. Epub 2012 Jan 11.
Abstract
An efficient synthetic strategy for rapid access to analogues of peloruside A has been demonstrated. The synthetic route was highlighted by a simple esterification-based fragment coupling and a late stage ring-closing metathesis reaction. This convergent route has provided access to rationally designed analogues inspired by the solution conformational preferences of peloruside A.
摘要
已经证明了一种快速获得 peloruside A 类似物的有效合成策略。该合成路线的特点是基于简单的酯化片段偶联和后期的环 closing metathesis 反应。这种收敛的路线为受 peloruside A 溶液构象偏好启发而设计的合理类似物提供了途径。
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