The Arnold and Mabel Beckman Laboratory of Chemical Synthesis, Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA.
Org Lett. 2010 Mar 5;12(5):984-7. doi: 10.1021/ol9029808.
A series of ruthenium catalysts have been screened under ring-closing metathesis (RCM) conditions to produce five-, six-, and seven-membered carbamate-protected cyclic amines. Many of these catalysts demonstrated excellent RCM activity and yields with as low as 500 ppm catalyst loadings. RCM of the five-membered carbamate series could be run neat, the six-membered carbamate series could be run at 1.0 M, and the seven-membered carbamate series worked best at 0.2-0.05 M.
已经筛选了一系列钌催化剂，以在闭环复分解（RCM）条件下生成五、六和七元氨甲酰基保护的环状胺。其中许多催化剂在低至 500ppm 的催化剂负载下表现出优异的 RCM 活性和产率。五元氨甲酰基系列的 RCM 可以在无溶剂条件下进行，六元氨甲酰基系列可以在 1.0 M 下进行，而七元氨甲酰基系列在 0.2-0.05 M 下效果最佳。
