Department of Dermatology, University of Athens, School of Medicine, Andreas Sygros Hospital, Athens, Greece.
Am J Clin Dermatol. 2010;11(2):95-102. doi: 10.2165/11530210-000000000-00000.
A rapidly increasing number of people visit dermatologists for the prevention and treatment of aging skin. Sun avoidance and sunscreen use are widely accepted strategies of primary prevention against photoaging. Convincing evidence shows that topical application of retinoids has an effect on reversing, at least partially, mild to moderate photodamage. Antioxidants and alpha-hydroxy acids can alter the skin structure and function. Enzymes that repair DNA damage or oligonucleotides that enhance the endogenous capacity for DNA damage repair may prove to be future preventive/therapeutic interventions for aging skin.
越来越多的人寻求皮肤科医生的帮助来预防和治疗皮肤衰老。避免阳光照射和使用防晒霜是预防光老化的主要策略，已被广泛接受。有充分的证据表明，局部应用维 A 酸对逆转轻度至中度光损伤至少有部分效果。抗氧化剂和 α-羟酸可以改变皮肤的结构和功能。修复 DNA 损伤的酶或增强 DNA 损伤修复内源性能力的寡核苷酸可能被证明是未来预防/治疗皮肤衰老的干预措施。
