Department of Psychology, University of California at Los Angeles, Los Angeles, CA 90095, USA.
Emotion. 2010 Feb;10(1):12-24. doi: 10.1037/a0018312.
To better understand the relationship between mindfulness and depression, we studied normal young adults (n = 27) who completed measures of dispositional mindfulness and depressive symptomatology, which were then correlated with (a) rest: resting neural activity during passive viewing of a fixation cross, relative to a simple goal-directed task (shape-matching); and (b) reactivity: neural reactivity during viewing of negative emotional faces, relative to the same shape-matching task. Dispositional mindfulness was negatively correlated with resting activity in self-referential processing areas, whereas depressive symptomatology was positively correlated with resting activity in similar areas. In addition, dispositional mindfulness was negatively correlated with resting activity in the amygdala, bilaterally, whereas depressive symptomatology was positively correlated with activity in the right amygdala. Similarly, when viewing emotional faces, amygdala reactivity was positively correlated with depressive symptomatology and negatively correlated with dispositional mindfulness, an effect that was largely attributable to differences in resting activity. These findings indicate that mindfulness is associated with intrinsic neural activity and that changes in resting amygdala activity could be a potential mechanism by which mindfulness-based depression treatments elicit therapeutic improvement.
为了更好地理解正念与抑郁之间的关系，我们研究了正常的年轻成年人（n=27），他们完成了特质正念和抑郁症状的测量，然后将其与（a）静息状态：与简单的目标导向任务（形状匹配）相比，被动观看固定十字时的静息神经活动；和（b）反应性：观看负面情绪面孔时的神经反应性，与相同的形状匹配任务相比。特质正念与自我参照处理区域的静息活动呈负相关，而抑郁症状与相似区域的静息活动呈正相关。此外，特质正念与双侧杏仁核的静息活动呈负相关，而抑郁症状与右杏仁核的活动呈正相关。同样，当观看情绪面孔时，杏仁核的反应性与抑郁症状呈正相关，与特质正念呈负相关，这种效应主要归因于静息活动的差异。这些发现表明正念与内在神经活动有关，而静息杏仁核活动的变化可能是正念为基础的抑郁治疗产生治疗效果的潜在机制。
