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抗抑郁药物的使用与物质滥用治疗中孕妇戒烟的关系。

The relationship between antidepressant use and smoking cessation in pregnant women in treatment for substance abuse.

机构信息

The Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

出版信息

Am J Drug Alcohol Abuse. 2010 Jan;36(1):46-51. doi: 10.3109/00952990903544844.

DOI:10.3109/00952990903544844
PMID:20141396
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2925391/
Abstract

BACKGROUND

Bupropion's efficacy for smoking cessation in pregnant women is unknown.

OBJECTIVES

To determine if substance-dependent women prescribed bupropion smoked fewer cigarettes/day than those prescribed citalopram/escitalopram or no antidepressant medication.

METHODS

Comparison of smoking in bupropion (n = 11), citalopram/escitalopram (n = 17), and no antidepressant (n = 28) groups.

RESULTS AND CONCLUSIONS

Trend for greater decrease in smoking for the bupropion vs. citalopram/escitalopram group [-6.4 vs. -.4 cigarettes/day (p = .276)], although the bupropion decrease was similar to that seen in the no antidepressant group [-5.3 cigarettes/day].

SCIENTIFIC SIGNIFICANCE

Data support continued study of bupropion in depressed pregnant substance-dependent smokers.

摘要

背景

安非他酮对于孕妇戒烟的疗效尚不明确。

目的

确定与服用西酞普兰/艾司西酞普兰或未服用抗抑郁药物相比，服用安非他酮的物质依赖女性每天吸烟的数量是否更少。

方法

比较安非他酮组（n = 11）、西酞普兰/艾司西酞普兰组（n = 17）和未用抗抑郁药组（n = 28）的吸烟情况。

结果和结论

安非他酮组比西酞普兰/艾司西酞普兰组的吸烟量下降趋势更大[-6.4 比 -.4 支/天（p =.276）]，尽管安非他酮的下降幅度与未用抗抑郁药组相似[-5.3 支/天]。

科学意义

数据支持在患有抑郁症的物质依赖吸烟孕妇中继续研究安非他酮。

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本文引用的文献

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The management of depression during pregnancy: a report from the American Psychiatric Association and the American College of Obstetricians and Gynecologists.孕期抑郁症的管理：美国精神病学协会和美国妇产科医师学会的报告
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Risk of preterm delivery and other adverse perinatal outcomes in relation to maternal use of psychotropic medications during pregnancy.孕期母亲使用精神药物与早产及其他不良围产期结局的风险
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阿片类药物依赖的孕妇接受美沙酮或丁丙诺啡治疗的吸烟状况比较。
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Survey of methadone-drug interactions among patients of methadone maintenance treatment program in Taiwan.台湾美沙酮维持治疗计划患者的美沙酮药物相互作用调查。
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对孕期和哺乳期用药的安全性进行分类。
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Counseling and interventions to prevent tobacco use and tobacco-caused disease in adults and pregnant women: U.S. Preventive Services Task Force reaffirmation recommendation statement.针对成年人及孕妇预防烟草使用和烟草所致疾病的咨询与干预：美国预防服务工作组重申推荐声明
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Incidence of major malformations in infants following antidepressant exposure in pregnancy: results of a large prospective cohort study.孕期暴露于抗抑郁药的婴儿中严重畸形的发生率：一项大型前瞻性队列研究的结果
Can J Psychiatry. 2009 Apr;54(4):242-6. doi: 10.1177/070674370905400405.
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Major depression and antidepressant treatment: impact on pregnancy and neonatal outcomes.重度抑郁症与抗抑郁药治疗：对妊娠及新生儿结局的影响
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Psychopharmacologic management of opioid-dependent women during pregnancy.孕期阿片类药物依赖女性的心理药理学管理
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A clinical practice guideline for treating tobacco use and dependence: 2008 update. A U.S. Public Health Service report.《治疗烟草使用和依赖的临床实践指南：2008年更新版》。美国公共卫生服务部报告。
Am J Prev Med. 2008 Aug;35(2):158-76. doi: 10.1016/j.amepre.2008.04.009.
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If nicotine is a developmental neurotoxicant in animal studies, dare we recommend nicotine replacement therapy in pregnant women and adolescents?如果在动物研究中尼古丁是一种发育神经毒物，我们敢在孕妇和青少年中推荐尼古丁替代疗法吗？
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