Division of Hematology/Oncology, The Warren Alpert Medical School of Brown University, The Miriam Hospital, Providence, RI 02906, USA.
Leuk Lymphoma. 2010 Mar;51(3):430-8. doi: 10.3109/10428190903572201.
Anaplastic large cell lymphoma (ALCL) is a distinct subtype of peripheral T-cell lymphoma (PTCL) characterized by the expression of CD30 in lymphoma cells. Like aggressive B-cell non-Hodgkin lymphoma, the risk of developing PTCL is also increased in the setting of HIV infection. To date, the occurrence of ALCL in HIV-positive individuals is limited to a few case reports and small case series. A total of 37 cases of HIV-associated ALCL were identified after reviewing the available published literature. Analysis of these cases showed that this group of HIV-infected patients was on average 38 years of age with a male-to-female ratio of 4:1, and a reported median CD4 cell count of 83 cells/mm(3). HIV-associated ALCL cells rarely expressed anaplastic lymphoma kinase. Epstein-Barr virus infection was associated with one-third of the cases. These lymphomas manifested almost exclusively with extranodal involvement and exhibited a very aggressive clinical course. The median overall survival was 5 months. The administration of chemotherapy and early stages at presentation were identified as good prognostic factors, while the use of HAART showed a statistical trend toward improved survival in HIV-associated ALCL.
间变大细胞淋巴瘤（ALCL）是一种独特的外周 T 细胞淋巴瘤（PTCL）亚型，其特征是淋巴瘤细胞表达 CD30。与侵袭性 B 细胞非霍奇金淋巴瘤一样，HIV 感染患者发生 PTCL 的风险也会增加。迄今为止，HIV 阳性个体中 ALCL 的发生仅限于少数病例报告和小病例系列。在回顾现有已发表文献后，共确定了 37 例与 HIV 相关的 ALCL。对这些病例的分析表明，这组 HIV 感染患者的平均年龄为 38 岁，男女比例为 4:1，报告的中位 CD4 细胞计数为 83 个/立方毫米。HIV 相关的 ALCL 细胞很少表达间变性淋巴瘤激酶。三分之一的病例与 EBV 感染有关。这些淋巴瘤几乎仅表现为结外受累，表现出非常侵袭性的临床病程。中位总生存期为 5 个月。化疗的应用和早期表现被确定为良好的预后因素，而 HAART 的使用显示出 HIV 相关 ALCL 生存改善的统计学趋势。
