Cohen Philip R, Prieto Victor G
The University of Houston Health Center, University of Houston, Houston, TX, USA.
J Cutan Pathol. 2010 Aug;37(8):891-4. doi: 10.1111/j.1600-0560.2010.01524.x. Epub 2010 Feb 5.
Xanthogranulomas are benign lesions composed of macrophages in which some of the cells have vacuolated cytoplasm. They commonly occur in children, referred to as juvenile xanthogranulomata, and are histopathologically characterized by the presence of Touton giant cells. Xanthogranuloma can also occur in adults. A woman who developed a solitary xanthogranuloma within the field of radiotherapy following treatment of her breast cancer is reported. In addition to xanthogranuloma, other benign lesions of keratinocytes, mast cells, endothelial cells and lymphatic cells have been observed at the site of radiation treatment. Also, several malignancies, including hematopoietic cancers, sarcomas, metastatic cancers and common skin cancers, have been observed within radiation ports. A causal relationship in the development of our patient's xanthogranuloma is suggested by the temporal association between the treatment with radiotherapy and the subsequent appearance of a xanthogranuloma directly within the radiation field.
黄色肉芽肿是由巨噬细胞组成的良性病变，其中一些细胞具有空泡化的细胞质。它们常见于儿童，称为幼年性黄色肉芽肿，组织病理学特征为存在杜顿巨细胞。黄色肉芽肿也可发生于成人。本文报道了一名女性在乳腺癌治疗后放疗区域内出现孤立性黄色肉芽肿的病例。除黄色肉芽肿外，在放疗部位还观察到角质形成细胞、肥大细胞、内皮细胞和淋巴细胞的其他良性病变。此外，在放疗区域内还观察到几种恶性肿瘤，包括造血系统癌症、肉瘤、转移性癌症和常见皮肤癌。放疗治疗与随后直接在放疗区域内出现黄色肉芽肿之间的时间关联提示了我们患者黄色肉芽肿发生的因果关系。
