Center of Excellence in Behavior Genetics, Department of Psychology, Abo Akademi University, Turku, Finland.
J Sex Med. 2010 Apr;7(4 Pt 1):1538-46. doi: 10.1111/j.1743-6109.2009.01696.x. Epub 2010 Feb 5.
Previous research has suggested brain dopamine (DA) neurotransmission to be involved in the control of ejaculation. Furthermore, previous studies indicate a partly hereditary background to premature ejaculation.
To investigate whether the dopamine transporter gene (DAT1) polymorphism is associated with premature ejaculation.
Retrospective self-reports of four indicators reflecting ejaculatory function-anteportal ejaculation, number of penile thrusts, ejaculation latency time, and feeling of control over ejaculation-and saliva samples for DNA analysis were obtained from 1,290 men (M = 26.9, standard deviation = 4.7 years; range 18-45) with sexual experience. Main Outcome Measures. Calculations of allelic effects were computed using the Generalized Estimating Equations module of SPSS 17.
Carriers of the 10R10R genotype had scores indicating a lower threshold to ejaculate on each of the indicators compared to the combined 9R9R/9R10R carrier group. The differences were significant both for the composite score and for anteportal ejaculation, number of thrusts, and feeling of control over ejaculation, but not for ejaculation latency time. The effect of the polymorphism remained significant after controlling for age, homosexual experience, having a regular sexual partner, level of sexual desire, and frequency of sexual activity, hence suggesting that it is not secondary to an association between the studied polymorphism and some other aspect of sexual behavior, but due to a specific influence of DA on ejaculation.
The findings of the present study support results of previous studies indicating involvement of dopaminergic neurotransmission in ejaculation.
先前的研究表明，大脑多巴胺（DA）神经递质参与射精的控制。此外，先前的研究表明，早泄有部分遗传背景。
研究多巴胺转运体基因（DAT1）多态性是否与早泄有关。
从 1290 名有性经验的男性（M=26.9，标准差=4.7 岁；年龄 18-45 岁）中获得反映射精功能的四个指标（前向射精、阴茎插入次数、射精潜伏期和对射精的控制感）的回顾性自我报告和唾液样本进行 DNA 分析。主要观察指标：使用 SPSS17 的广义估计方程模块计算等位基因效应的计算。
与 9R9R/9R10R 携带者组相比，携带 10R10R 基因型的个体在每个指标上的射精阈值评分均较低。复合评分、前向射精、插入次数和对射精的控制感差异均有统计学意义，但射精潜伏期无差异。在控制年龄、同性恋经历、有固定性伴侣、性欲水平和性行为频率后，多态性的影响仍然显著，这表明它不是由于所研究的多态性与性行为的某些其他方面有关，而是由于 DA 对射精的特定影响。
本研究的结果支持先前研究的结果，表明多巴胺能神经传递参与射精。
