Department of Pharmacology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Göteborg, Sweden.
Arch Sex Behav. 2013 Jan;42(1):45-9. doi: 10.1007/s10508-012-9991-x. Epub 2012 Jul 19.
A population-based sample of 1673 (valid phenotypic and genotypic data were available from 1412 individuals) Finnish male twins and siblings of twins aged 18-45 years provided questionnaire data regarding ejaculatory function as well as saliva samples for genotype analyses. Genotypic analyses were conducted controlling for between-subjects dependence. No significant association was found between the 5-HTTLPR polymorphism and a composite variable measuring premature ejaculation or between this polymorphism and a self-report measure of ejaculation latency time. Previously conducted studies have found contradicting results regarding the possible role of 5-HTTLPR in premature ejaculation. Methodological inconsistencies have been pointed out in these studies, which have all been conducted on rather small samples. While differences in terms of measurement of ejaculatory function could partly explain why positive findings from some earlier studies could not be replicated, the present study, given the large sample size and multifactorial measures used, indicated that the 5-HTTLPR polymorphism has a limited, if any, impact on ejaculatory function.
一项基于人群的研究对 1673 名（1412 名个体具有有效表型和基因型数据）18-45 岁的芬兰男性双胞胎及其双胞胎兄弟姐妹进行了研究，收集了有关射精功能的问卷调查数据和唾液样本进行基因分型分析。基因分型分析在控制个体间依赖关系的情况下进行。5-HTTLPR 多态性与衡量早泄的综合变量之间或与自我报告的射精潜伏期之间均未发现显著相关性。先前的研究表明 5-HTTLPR 在早泄中的可能作用存在矛盾的结果。这些研究存在方法学上的不一致，并且所有研究的样本量都较小。虽然在射精功能的测量方面存在差异，这可能部分解释了为什么一些早期研究的阳性结果无法得到重复，但本研究由于样本量大且采用了多因素测量，表明 5-HTTLPR 多态性对射精功能的影响有限，如果有的话。
