Luo Shun-wen, Wang Feng, Xie Zhi-yuan, Huang Xiao-ke, Lu Yi-ping
Department of Urology, West China Hospital, Sichuan University, Chengdu 610041, China.
Beijing Da Xue Xue Bao Yi Xue Ban. 2011 Aug 18;43(4):514-8.
To investigate the relationship between 5-HT transporter gene-linked polymorphism (5-HTTPLR) and the clinical characters of premature ejaculation in Han Chinese population.
By case-control study approach, we set primary premature ejaculation (PPE) group (119 cases), secondary premature ejaculation (SPE) group (60 cases) with IELT < 1 min in more than 90% coitus and normal control group (90 cases) with IELT ≥ 3 min. The gene polymorphism of the 5-HTT was detected by polymerase chain reaction analysis in all the cases, and the gene frequency differences among the three groups were evaluated.
The frequency of the genotype S/S was higher in PPE group than in normal control group(51.3% vs. 37.8%,P<0.01), and the frequency of genetype L/S was lower in PPE group than in normal vontrol group(28.6% vs. 34.4%,P<0.05).The S allele was higher in PPE group than in control group (P<0.05), but there was no difference between the SPE group and the normal control group.
The 5-HTTLPR polymorphism is associated with PPE, which shows that genetics may play an important role in the occurrence of PPE but not of SPE. The etiology of PPE and SPE is different.
探讨5-羟色胺转运体基因连锁多态性（5-HTTPLR）与汉族人群早泄临床特征之间的关系。
采用病例对照研究方法，设立原发性早泄（PPE）组（119例）、继发性早泄（SPE）组（60例，90%以上性交时阴道内射精潜伏期（IELT）<1分钟）和正常对照组（90例，IELT≥3分钟）。对所有病例采用聚合酶链反应分析检测5-HTT基因多态性，并评估三组间基因频率差异。
PPE组中基因型S/S的频率高于正常对照组（51.3%对37.8%，P<0.01），PPE组中基因型L/S的频率低于正常对照组（28.6%对34.4%，P<0.05）。PPE组中S等位基因频率高于对照组（P<0.05），但SPE组与正常对照组之间无差异。
5-HTTLPR多态性与PPE相关，这表明遗传学可能在PPE的发生中起重要作用，但在SPE的发生中不起作用。PPE和SPE的病因不同。
