Maternal Nutrition Group, Department of Epidemiology Research, Statens Serum Institut, Artillerivej 5, 2300 Copenhagen, Denmark.
J Clin Psychiatry. 2009 Dec;70(12):1707-14. doi: 10.4088/JCP.09m05012blu.
To explore the association between physical activity during pregnancy and postpartum depression (PPD) in a large, prospective cohort.
Exposure information from the Danish National Birth Cohort, a large, prospective cohort with information on more than 100,000 pregnancies (1996-2002), was linked to the Danish Psychiatric Central Register and the Danish Register for Medicinal Product Statistics for data on clinically identified cases of depression up to 1 year postpartum. A total of 70,866 women from the Danish National Birth Cohort were included in the analyses. Duration, frequency, and type of physical activity were assessed by a telephone interview at approximately week 12 of gestation. Admission to hospital due to depression (PPD-admission) and prescription of an antidepressant (PPD-prescription) were treated as separate outcomes.
Through linkage to national registers, we identified 157 cases of PPD-admission and 1,305 cases of PPD-prescription. Women engaging in vigorous physical activity during pregnancy had a lower risk of PPD-prescription compared to women who were not physically active (adjusted odds ratio, 0.81; 95% CI, 0.66-0.99). No association was observed between physical activity and PPD-admission; but, in women who were underweight prior to pregnancy, physical activity was associated with increased risk of PPD-admission.
Our data are compatible with a protective effect of vigorous physical activity, but not for other measures of physical activity, against postpartum depression requiring antidepressant therapy. No protective effect could be detected on PPD leading to hospitalization.
在一个大型前瞻性队列中探讨孕期和产后体力活动与产后抑郁症（PPD）的关系。
通过链接丹麦国家出生队列的暴露信息，该队列是一个大型前瞻性队列，包含超过 100,000 例妊娠（1996-2002 年）的信息，与丹麦精神病中央登记处和丹麦药品统计登记处相关联，以获取产后 1 年内临床确诊的抑郁症病例数据。共有 70,866 名丹麦国家出生队列的妇女纳入分析。孕期约 12 周时通过电话访谈评估体力活动的持续时间、频率和类型。因抑郁症（PPD-入院）住院和开抗抑郁药（PPD-处方）被视为独立结局。
通过与国家登记处的链接，我们确定了 157 例 PPD-入院和 1,305 例 PPD-处方病例。与不进行体力活动的女性相比，孕期进行剧烈体力活动的女性患 PPD-处方的风险较低（调整后的优势比，0.81；95%置信区间，0.66-0.99）。体力活动与 PPD-入院之间没有关联；但是，在怀孕前体重不足的女性中，体力活动与 PPD-入院的风险增加相关。
我们的数据与剧烈体力活动对产后抑郁症（需要抗抑郁治疗）具有保护作用一致，但其他体力活动措施则不然。对导致住院的 PPD 没有检测到保护作用。
