Da Fonseca D, Fakra E
Service de Pédopsychiatrie, Hôpital Sainte Marguerite, and Pôle Universitaire de Psychiatrie, 270 BD Sainte Marguerite 13009, Marseille.
Encephale. 2010 Jan;36 Suppl 1:S3-7. doi: 10.1016/S0013-7006(10)70002-6.
The study of the premorbid functioning in bipolar disorder allows us to identify several risk factors of the disease. First we will present retrospective studies of adults or teenagers presenting a bipolar disorder and second the studies concerning offspring of parents with bipolar disorder. Despite contradictory results and methodological weaknesses, these studies indicate that anxious disorders and childhood disruptive behaviour disorders may be useful markers of risk for adult bipolar disorder. All these results may open up several interesting perspectives for the prevention ant the treatment of bipolar disorder.
对双相情感障碍病前功能的研究使我们能够识别该疾病的多种风险因素。首先，我们将介绍针对患有双相情感障碍的成年人或青少年的回顾性研究，其次是关于双相情感障碍患者后代的研究。尽管存在相互矛盾的结果和方法上的缺陷，但这些研究表明，焦虑症和儿童期破坏性行为障碍可能是成人双相情感障碍风险的有用标志物。所有这些结果可能为双相情感障碍的预防和治疗开辟几个有趣的前景。
