Quarello E
Hôpital Saint-Joseph, Pôle Parents-Enfants, Unité d'échographie obstétricale, Service de gynécologie-obstétrique, 26, bd de Louvain, 13285 Marseille cedex 8, France.
J Gynecol Obstet Biol Reprod (Paris). 2009 Dec;38(8 Suppl):S31-8. doi: 10.1016/S0368-2315(09)73557-4.
To determine the most efficient and tailored screening method for aneuploidies in twins for the French population.
Articles were searched using the PubMed and the Cochrane libraries.
In cases of twin pregnancies, the aneuploidy's risk related to maternal age as well as gestational age must be considered as being the same as in singletons. In bichorionic twins, we have to consider individually the nuchal translucency thickness of each twin. In monochorionic twins, we have to consider a range of risks related to the nuchal translucency measurements of each twins. The additional benefit of maternal serum biochemistry screening in twins is not as established as in singletons.
The most appropriate method of screening for aneuploidies in twin pregnancies is based during the first trimester of pregnancy on the risk related to maternal age combined with those related to the nuchal translucency measurement. In the absence of first-trimester screening, it is possible to offer a screening method based on the second trimester maternal serum biochemistry and/or by a targeted ultrasound.
为法国人群确定最有效且量身定制的双胎非整倍体筛查方法。
通过PubMed和Cochrane图书馆检索文章。
在双胎妊娠的情况下，与单胎妊娠一样，必须将与母亲年龄以及孕周相关的非整倍体风险视为相同。在双绒毛膜双胎中，我们必须分别考虑每个胎儿的颈项透明层厚度。在单绒毛膜双胎中，我们必须考虑与每个胎儿颈项透明层测量相关的一系列风险。双胎妊娠中母体血清生化筛查的额外益处不像单胎妊娠那样明确。
双胎妊娠非整倍体筛查的最合适方法是在妊娠早期基于与母亲年龄相关的风险以及与颈项透明层测量相关的风险。在没有早期筛查的情况下，可以提供基于孕中期母体血清生化和/或靶向超声的筛查方法。
