Immunobiology Unit, Instituto de Medicina Molecular, Faculdade de Medicina de Lisboa, 1649-028 Lisboa, Portugal.
J Exp Med. 2010 Feb 15;207(2):269-72. doi: 10.1084/jem.20100105. Epub 2010 Feb 8.
A population of cells that expresses the NK cell receptor NKp46 and produces interleukin (IL)-22 have recently attracted considerable attention. The identity of these cells is still the subject of speculation, being variably defined as a novel NK cell subset or as a population containing conventional NK (cNK) cell precursors. In this issue, two studies shed light on this conundrum, demonstrating that NKp46(+) IL-22(+) cells and cNK cells belong to distinct lineages.
最近，一群表达自然杀伤细胞受体 NKp46 并产生白细胞介素 (IL)-22 的细胞引起了相当大的关注。这些细胞的身份仍在推测之中，它们被不同地定义为一种新型的 NK 细胞亚群或包含常规 NK（cNK）细胞前体的群体。在本期中，两项研究阐明了这一难题，表明 NKp46(+)IL-22(+)细胞和 cNK 细胞属于不同的谱系。
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