School of Nursing, University of California, Los Angeles, CA 90095-6916, USA.
Cancer Nurs. 2010 Mar-Apr;33(2):85-92. doi: 10.1097/NCC.0b013e3181be5e51.
Data about health-related quality of life (QOL) after surgical treatment for lung cancer are limited. Such information can be valuable in developing appropriate nursing interventions for follow-up care for survivors.
The purposes of this study were to describe physical and emotional QOL of disease-free female non-small cell lung cancer (NSCLC) survivors and to determine characteristics associated with greater risk for disruptions.
One-hundred-nineteen women surgically treated for NSCLC completed the Short-Form 36 (as a measure of physical and mental QOL) along with health status assessments (including comorbidity, depression, Center for Epidemiologic Studies-Depression Scale, smoking status, and body mass index), dyspnea (Dyspnea Index), meaning of illness, and demographic and clinical information at baseline and 3 and 6 months.
On average, the women were 68 years of age, diagnosed 2 years previously, had adenocarcinoma, and were treated surgically with lobectomy. The majority (66%) had comorbid disease, 29% had depressed mood (Center for Epidemiologic Studies-Depression Scale score > or =16), 8% were current smokers, 62% were overweight, 22% had dyspnea (scores > or =2), and 24% had a negative meaning of illness. Physical and emotional QOL scores were comparable to Short-Form 36 norms for older adults and exhibited little change over time. Controlling for time since diagnosis, dyspnea, and depressed mood were strongly related to disruptions in physical and emotional QOL, respectively, across the 6-month study period, with comorbid disease contributing to both models.
Depressed mood, comorbidities, and dyspnea were factors related to poorer physical and emotional QOL. Survivors with these characteristics might benefit from greater supportive care.
Screening for dyspnea, depressed mood, and comorbid illness can identify female survivors at-risk for poorer QOL after surgery.
有关肺癌手术后健康相关生活质量（QOL）的数据有限。这些信息对于为幸存者的后续护理制定适当的护理干预措施非常有价值。
本研究的目的是描述无病女性非小细胞肺癌（NSCLC）幸存者的身体和情绪 QOL，并确定与更大风险相关的特征。
119 名接受 NSCLC 手术治疗的女性完成了简明 36 项健康调查（作为身体和心理 QOL 的衡量标准），以及健康状况评估（包括合并症、抑郁、流行病学研究中心抑郁量表、吸烟状况和体重指数）、呼吸困难（呼吸困难指数）、疾病意义以及人口统计学和临床信息，基线和 3 个月和 6 个月。
平均而言，这些女性的年龄为 68 岁，诊断为 2 年前，患有腺癌，并接受肺叶切除术治疗。大多数（66%）患有合并症，29%的女性情绪低落（流行病学研究中心抑郁量表评分≥16），8%为当前吸烟者，62%超重，22%呼吸困难（评分≥2），24%对疾病持负面态度。身体和情绪 QOL 评分与老年人的简明 36 项评分标准相当，且随着时间的推移变化不大。控制诊断后时间、呼吸困难和抑郁情绪后，在整个 6 个月的研究期间，这三个因素分别与身体和情绪 QOL 的中断密切相关，合并症对两个模型都有贡献。
抑郁情绪、合并症和呼吸困难是与较差的身体和情绪 QOL 相关的因素。具有这些特征的幸存者可能需要更多的支持性护理。
呼吸困难、抑郁情绪和合并症的筛查可以识别手术后 QOL 较差的女性幸存者。
