Cao Luchang, Wang Zilin, Wang Xinmiao, Zhu Guanghui, Zhang Ying, Li Jie
Guang 'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
Integr Cancer Ther. 2025 Jan-Dec;24:15347354251313533. doi: 10.1177/15347354251313533.
The incidence and mortality of lung cancer is the highest among malignant tumors worldwide, and it seriously threatens human life and health. Surgery is the primary radical treatment for lung cancer. However, patients often experience discomfort, changes in social roles, economic pressures, and other postsurgical challenges. These factors frequently cause various psychological disorders such as anxiety and depression, significantly diminishing the quality of life and elevating the risks of recurrence, metastasis, and mortality. Therefore, effective strategies for mental function rehabilitation should be urgently developed. Traditional Chinese medicine can significantly improve psychological function and physical symptoms after lung cancer surgery, and prolong patient survival. However, its effectiveness for mental function rehabilitation after lung cancer surgery remains unclear. This study aimed to investigate the effects of Chinese medicine on mental function recovery after lung cancer surgery through a systematic review and meta-analysis.
This study will systematically search the following databases: PubMed, Cochrane Library, EMBASE, Web of Science, ClinicalTrials.gov, China National Knowledge Infrastructure, database, VIP database, and Chinese BioMedical Literature database. Search for studies published from the inception of each database until April 22, 2024. This study will be limited to clinical randomized controlled trials (RCTs). The primary outcome will be depression or anxiety, as indicated by the scale score. Data analysis will be performed using RevMan 5. The Cochrane Risk of Bias Assessment Tool will be used to evaluate the quality of included studies. Finally, the quality of the evidence will be classified using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) System.
This meta-analysis aims to offer comprehensive evidence of the effectiveness of traditional Chinese medicine in mental function rehabilitation after lung cancer surgery. The study will assess the quality of the reports and conduct a subgroup analysis based on various postoperative stages, intervention measures, intervention duration, and sex to gather more evidence to fill the gap in psychological function rehabilitation after lung cancer surgery. These data can be used to guide clinical practice and inform future studies. More importantly, the results of this study will provide evidence to support the development of expert consensus and clinical guidelines in the field of mental function rehabilitation after lung cancer surgery.
肺癌的发病率和死亡率在全球恶性肿瘤中位居首位，严重威胁人类生命健康。手术是肺癌的主要根治性治疗方法。然而，患者术后常经历不适、社会角色改变、经济压力等挑战。这些因素常导致焦虑和抑郁等各种心理障碍，显著降低生活质量，增加复发、转移和死亡风险。因此，迫切需要制定有效的心理功能康复策略。中医可显著改善肺癌术后的心理功能和身体症状，并延长患者生存期。然而，其对肺癌术后心理功能康复的有效性尚不清楚。本研究旨在通过系统评价和荟萃分析探讨中医对肺癌术后心理功能恢复的影响。
本研究将系统检索以下数据库：PubMed、Cochrane图书馆、EMBASE、Web of Science、ClinicalTrials.gov、中国知网数据库、维普数据库和中国生物医学文献数据库。检索各数据库建库至2024年4月22日发表的研究。本研究将限于临床随机对照试验（RCT）。主要结局将为量表评分所示的抑郁或焦虑。将使用RevMan 5进行数据分析。将使用Cochrane偏倚风险评估工具评估纳入研究的质量。最后，将使用推荐分级评估、制定与评价（GRADE）系统对证据质量进行分类。
本荟萃分析旨在提供中医对肺癌术后心理功能康复有效性的全面证据。该研究将评估报告质量，并根据不同术后阶段、干预措施、干预持续时间和性别进行亚组分析，以收集更多证据填补肺癌术后心理功能康复方面的空白。这些数据可用于指导临床实践并为未来研究提供信息。更重要的是，本研究结果将为支持肺癌术后心理功能康复领域专家共识和临床指南的制定提供证据。
