Halms Theresa, Strasser Martina, Hasan Alkomiet, Rüther Tobias, Rabenstein Andrea, Trepel Martin, Raab Stephan, Gertzen Marcus
Department of Psychiatry and Psychotherapy, Medical Faculty, University of Augsburg, Geschwister-Schönert Straße 1, 86156, Augsburg, Germany.
DZPG (German Center for Mental Health), partner site Munich/Augsburg, Augsburg, Germany.
Eur Arch Psychiatry Clin Neurosci. 2025 Aug 28. doi: 10.1007/s00406-025-02086-w.
Lung cancer (LC) is a leading cause of cancer-related mortality, with smoking being a major risk factor. Despite the benefits of smoking cessation, many LC patients continue to smoke, potentially impacting their quality of life (QoL). This study aimed to explore factors influencing QoL among LC patients, with a focus on smoking status and mental health.
A cross-sectional study was conducted at the University Hospital of Augsburg from December 2021 to December 2023. A total of 56 LC patients were categorized into active smokers (AS), ex-smokers (ES), or never-smokers (NS). Participants completed validated questionnaires assessing QoL, depression, anxiety, stress, borderline personality disorder symptoms, and pain. Statistical analyses, including one-way ANOVA and Pearson's correlation, were employed to examine group differences and the relationship between QoL and mental health factors.
No significant differences in overall QoL were observed among AS, ES, and NS. However, mental health indicators-including depression, anxiety, stress, and borderline personality disorder symptoms-were significantly negatively correlated with QoL across all groups. Pain was also a key factor affecting QoL. These findings suggest that while smoking cessation is critical for improving prognosis in LC patients, mental health and pain management are more pivotal in determining QoL.
This study emphasizes the need for a holistic approach to LC patient care, addressing both physical and mental health. Future research should focus on longitudinal studies to better understand the long-term effects of smoking and other influencing factors on QoL in this patient population.
肺癌（LC）是癌症相关死亡的主要原因，吸烟是主要危险因素。尽管戒烟有益，但许多肺癌患者仍继续吸烟，这可能会影响他们的生活质量（QoL）。本研究旨在探讨影响肺癌患者生活质量的因素，重点关注吸烟状况和心理健康。
2021年12月至2023年12月在奥格斯堡大学医院进行了一项横断面研究。共有56名肺癌患者被分为现吸烟者（AS）、既往吸烟者（ES）或从不吸烟者（NS）。参与者完成了评估生活质量、抑郁、焦虑、压力、边缘性人格障碍症状和疼痛的有效问卷。采用包括单因素方差分析和Pearson相关性分析在内的统计分析方法来检验组间差异以及生活质量与心理健康因素之间的关系。
在现吸烟者、既往吸烟者和从不吸烟者之间未观察到总体生活质量的显著差异。然而，心理健康指标——包括抑郁、焦虑、压力和边缘性人格障碍症状——在所有组中均与生活质量显著负相关。疼痛也是影响生活质量的关键因素。这些发现表明，虽然戒烟对改善肺癌患者的预后至关重要，但心理健康和疼痛管理在决定生活质量方面更为关键。
本研究强调了对肺癌患者进行全面护理的必要性，包括关注身心健康。未来的研究应侧重于纵向研究，以更好地了解吸烟和其他影响因素对该患者群体生活质量的长期影响。
