Siegelman E S, Mitchell D G, Rubin R, Hann H W, Kaplan K R, Steiner R M, Rao V M, Schuster S J, Burk D L, Rifkin M D
Department of Radiology, Thomas Jefferson University Hospital, Philadelphia, PA.
Radiology. 1991 May;179(2):361-6. doi: 10.1148/radiology.179.2.2014275.
Parenchymal iron deposition occurs in hemochromatosis, while iron is deposited in reticuloendothelial (RE) cells after blood transfusions or rhabdomyolysis. Magnetic resonance images of patients with decreased liver signal intensity on T2-weighted images at 1.5 T were blindly compared in an effort to distinguish these conditions. In each of five patients with hemochromatosis, the pancreas had low signal intensity, but splenic signal intensity was decreased in only one. In contrast, only three of the 16 patients with RE iron overload had low pancreatic signal intensity, while all of these patients either had low splenic signal intensity (n = 14) or previously underwent splenectomy (n = 2). Distinction among these causes of iron deposition is clinically important because parenchymal iron overload from hemochromatosis may produce significant tissue damage, while the RE iron of transfusions and rhabdomyolysis is of little clinical consequence.
实质铁沉积发生在血色素沉着症中，而输血或横纹肌溶解后铁沉积在网状内皮（RE）细胞中。为了区分这些情况，对1.5T时T2加权图像上肝脏信号强度降低的患者的磁共振图像进行了盲法比较。在五名血色素沉着症患者中，胰腺信号强度均较低，但仅一名患者脾脏信号强度降低。相比之下，16名RE铁过载患者中只有三名胰腺信号强度较低，而所有这些患者要么脾脏信号强度较低（n = 14），要么之前接受过脾切除术（n = 2）。区分这些铁沉积原因在临床上很重要，因为血色素沉着症引起的实质铁过载可能会导致严重的组织损伤，而输血和横纹肌溶解引起的RE铁对临床影响较小。
