Department of Physical Medicine and Rehabilitation, College of Medicine, Seoul National University, Boramae Medical Center, 395 Shindaebang 2 dong, Dongjak ku, Seoul, Korea.
Med Sci Sports Exerc. 2010 Sep;42(9):1625-31. doi: 10.1249/MSS.0b013e3181d58e09.
Repetitive limb movements made during aerobic exercises, such as walking and jogging that are frequently prescribed for diabetes control, can induce nerve strain, which has been reported to induce nerve ischemia. Nerves in a diabetic background are more vulnerable to ischemia. We investigated the effects of repetitive treadmill and swimming exercises on nerves in diabetic rats.
Rats with diabetic neuropathy were randomly allocated to one of three groups, namely, control (n = 7), treadmill (n = 8), and swimming (n = 8) groups. After 12 wk of exercise, sural and sciatic nerves were harvested and analyzed by Terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) and Western blotting.
In sural nerves, percentages of TUNEL-positive cells and BAX/GAPDH level were higher in the treadmill than that in the swimming group. In sciatic nerves, there was no significant difference among three groups.
: Endurance exercises increase Schwann cell apoptosis in distal peripheral nerves. Greater loadings during exercise were found to increase Schwann cell apoptosis. Land-based endurance exercises may have a harmful effect on peripheral nerves in certain individuals with diabetes.
在糖尿病控制中经常规定的有氧运动（如步行和慢跑）中进行重复的肢体运动可能会导致神经紧张，据报道这会导致神经缺血。糖尿病背景下的神经更容易缺血。我们研究了重复跑步机和游泳运动对糖尿病大鼠神经的影响。
患有糖尿病性神经病的大鼠被随机分配到三个组之一，即对照组（n = 7）、跑步机组（n = 8）和游泳组（n = 8）。经过 12 周的运动后，收获腓肠神经和坐骨神经，并通过末端脱氧核苷酸转移酶 dUTP 缺口末端标记（TUNEL）和 Western blot 进行分析。
在腓肠神经中，跑步机组的 TUNEL 阳性细胞百分比和 BAX/GAPDH 水平高于游泳组。在坐骨神经中，三组之间没有显著差异。
耐力运动增加了远端周围神经中的雪旺细胞凋亡。运动时的负荷越大，雪旺细胞凋亡越多。陆地耐力运动可能对某些糖尿病患者的周围神经产生有害影响。
