Department of Physiology, College of Medicine, Kyung Hee University, Seoul, Republic of Korea.
Exp Gerontol. 2010 May;45(5):357-65. doi: 10.1016/j.exger.2010.02.005. Epub 2010 Feb 13.
Aging leads to functional changes in the hippocampus, and consequently induces cognitive deficits, such as failure of memory. Neurogenesis in the hippocampal dentate gyrus continues throughout life, but steadily declines from early adulthood. Apoptosis occurs under various pathologic and physiologic conditions, and excessive apoptotic cell death can cause a number of functional disorders in humans. Apoptosis in the hippocampus also disturbs cognitive functions. In this study, we examined the effect of treadmill exercise on memory in relation to neurogensis and apoptosis in the hippocampal dentate gyrus of old-aged rats. The present results showed that loss of memory by aging was associated with a decrease in neurogenesis and an increase in apoptosis in the hippocampal dentate gyrus. Treadmill exercise improved short-term and spatial memories by enhancing neurogenesis and suppressing apoptosis in the hippocampal dentate gyrus of old-aged rats. In the present study, we showed that treadmill exercise is a very useful strategy for preventing failure of memory in the elderly.
衰老是导致海马功能变化的原因，进而导致认知缺陷，如记忆丧失。海马齿状回中的神经发生在整个生命过程中持续存在，但从成年早期开始稳步下降。细胞凋亡发生在各种病理和生理条件下，过多的凋亡细胞死亡会导致人类许多功能障碍。海马中的细胞凋亡也会扰乱认知功能。在这项研究中，我们研究了跑步机运动对老年大鼠海马齿状回神经发生和细胞凋亡与记忆之间关系的影响。目前的结果表明，衰老导致的记忆丧失与海马齿状回神经发生减少和细胞凋亡增加有关。跑步机运动通过增强老年大鼠海马齿状回的神经发生和抑制细胞凋亡，改善了短期和空间记忆。在本研究中，我们表明跑步机运动是预防老年人记忆丧失的非常有用的策略。
