Public Health and Health Policy, Division of Community Based Sciences, Faculty of Medicine, University of Glasgow, Glasgow, UK.
Int J Obes (Lond). 2010 Jun;34(6):1051-9. doi: 10.1038/ijo.2010.20. Epub 2010 Feb 9.
To analyse the relationship between body mass index (BMI) and liver disease in men and women.
The Midspan prospective cohort studies.
The three studies were: Main study, screened in 1965-1968, workplaces across Scotland, the general population of the island of Tiree and mainland relatives; Collaborative study, conducted from 1970 to 1973, 27 workplaces in Glasgow, Clydebank and Grangemouth; Renfrew/Paisley general population study, screened in 1972-1976. After exclusions there were 16 522 men and 10 216 women, grouped by BMI into under/normal weight (< 25 kg m(-2)), overweight (25 to < 30 kg m(-2)) and obese (>or=30 kg m(-2)).
Relative rates (RRs) of liver disease mortality, subdivided into liver cancer and all other liver disease, by BMI category and per s.d. increase in BMI, followed-up to end 2007. RRs of liver disease from any diagnosis on the death certificate, hospital discharge records or cancer registrations (Collaborative and Renfrew/Paisley studies only 13 027 men and 9328 women). Analyses adjusted for age and study, then other confounders.
In total, 146 men (0.9%) and 61 women (0.6%) died of liver disease as main cause. There were strong associations of BMI with liver disease mortality in men (RR per s.d. increase in BMI=1.41 (95% confidence interval 1.21-1.65)). Obese men had more than three times the rate of liver disease mortality than under/normal weight men. Adjustment for other risk factors had very little effect. No substantial or robust associations were observed in women. In all, 325 men (2.5%) and 155 women (1.7%) had liver disease established from any source. Similar positive associations were observed for men, and there was evidence of a relationship in women.
BMI is related to liver disease, although not to liver disease mortality in women. The current rise in overweight and obesity may lead to a continuing epidemic of liver disease.
分析男性和女性体重指数（BMI）与肝病之间的关系。
中跨度前瞻性队列研究。
三项研究分别为：主要研究，1965-1968 年筛选，苏格兰各地的工作场所，提利岛和大陆的普通人群以及亲属；合作研究，1970 年至 1973 年进行，格拉斯哥、克莱德班克和格兰杰默斯的 27 个工作场所；伦弗鲁/佩斯利普通人群研究，1972-1976 年筛选。排除后，有 16522 名男性和 10216 名女性，根据 BMI 分为低体重/正常体重（<25kg/m2）、超重（25 至<30kg/m2）和肥胖（>=30kg/m2）。
BMI 类别和 BMI 每增加一个标准差的肝疾病死亡率的相对比率（RR），随访至 2007 年底。任何诊断的肝疾病死亡率，包括死亡证明、出院记录或癌症登记（合作和伦弗鲁/佩斯利研究仅 13027 名男性和 9328 名女性）。分析调整了年龄和研究因素，然后是其他混杂因素。
共有 146 名男性（0.9%）和 61 名女性（0.6%）死于肝疾病。BMI 与男性肝疾病死亡率呈强相关（BMI 每增加一个标准差的 RR=1.41（95%置信区间 1.21-1.65））。肥胖男性的肝疾病死亡率是低体重/正常体重男性的三倍多。调整其他危险因素的影响很小。在女性中未观察到实质性或稳健的关联。共有 325 名男性（2.5%）和 155 名女性（1.7%）通过任何来源确定患有肝疾病。男性也观察到类似的正相关，女性也有证据表明存在这种关系。
BMI 与肝疾病有关，尽管与女性肝疾病死亡率无关。目前超重和肥胖的增加可能导致肝疾病的持续流行。
