Institute of Health & Wellbeing, College of Medical, Veterinary and Life Sciences, Public Health, University of Glasgow, 1 Lilybank Gardens, Glasgow G12 8RZ, UK.
Nutr J. 2012 Jun 13;11:42. doi: 10.1186/1475-2891-11-42.
Higher consumption of coffee intake has recently been linked with reduced risk of aggressive prostate cancer (PC) incidence, although meta-analysis of other studies that examine the association between coffee consumption and overall PC risk remains inconclusive. Only one recent study investigated the association between coffee intake and grade-specific incidence of PC, further evidence is required to understand the aetiology of aggressive PCs. Therefore, we conducted a prospective study to examine the relationship between coffee intake and overall as well as grade-specific PC risk.
We conducted a prospective cohort study of 6017 men who were enrolled in the Collaborative cohort study in the UK between 1970 and 1973 and followed up to 31st December 2007. Cox Proportional Hazards Models were used to evaluate the association between coffee consumption and overall, as well as Gleason grade-specific, PC incidence.
Higher coffee consumption was inversely associated with risk of high grade but not with overall risk of PC. Men consuming 3 or more cups of coffee per day experienced 55% lower risk of high Gleason grade disease compared with non-coffee drinkers in analysis adjusted for age and social class (HR 0.45, 95% CI 0.23-0.90, p value for trend 0.01). This association changed a little after additional adjustment for Body Mass Index, smoking, cholesterol level, systolic blood pressure, tea intake and alcohol consumption.
Coffee consumption reduces the risk of aggressive PC but not the overall risk.
最近的研究表明，较高的咖啡摄入量与侵袭性前列腺癌（PC）发病风险降低有关，尽管对其他研究中咖啡摄入量与总体 PC 风险之间的关联进行的荟萃分析仍存在争议。仅有一项近期研究调查了咖啡摄入量与特定等级 PC 发病之间的关系，需要进一步的证据来了解侵袭性 PC 的病因。因此，我们进行了一项前瞻性研究，以检验咖啡摄入量与总体以及特定等级 PC 风险之间的关系。
我们对 1970 年至 1973 年期间参加英国合作队列研究的 6017 名男性进行了前瞻性队列研究，并随访至 2007 年 12 月 31 日。Cox 比例风险模型用于评估咖啡摄入量与总体以及 Gleason 分级特异性 PC 发病风险之间的关系。
较高的咖啡摄入量与高级别 PC 风险呈负相关，但与总体 PC 风险无关。在调整年龄和社会阶层后，每天饮用 3 杯或更多杯咖啡的男性与非咖啡饮用者相比，高级别 Gleason 分级疾病的风险降低了 55%（HR 0.45，95%CI 0.23-0.90，趋势检验的 p 值为 0.01）。在进一步调整体重指数、吸烟、胆固醇水平、收缩压、茶摄入量和饮酒量后，该关联略有变化。
咖啡摄入量降低了侵袭性 PC 的风险，但不能降低总体风险。
