糖尿病和患有慢性广泛性牙周炎的健康受试者中性粒细胞功能的比较。
Comparison of neutrophil functions in diabetic and healthy subjects with chronic generalized periodontitis.
作者信息
Shetty Neetha, Thomas Biju, Ramesh Amita
机构信息
Assistant Professor, Department of Periodontics, MCODS, Mangalore, India.
出版信息
J Indian Soc Periodontol. 2008 May;12(2):41-4. doi: 10.4103/0972-124X.44089.
Abstract
BACKGROUND
Diabetes mellitus is a systemic condition that has long been associated with an increased risk and severity of periodontal disease. Polymorphonuclear leukocytes (PMNs) play a key role in the maintenance of gingival and periodontal health. Reduced PMN function has been found in patients with diabetes.
AIM
The objective of this study was to evaluate PMN functions in 15 diabetic patients with chronic generalized periodontitis.
MATERIALS AND METHODS
Chemotaxis, superoxide production, phagocytosis and killing of Porphyromonas gingivalis by diabetic PMNs were evaluated relative to healthy and matched controls.
RESULTS
These analyses revealed a significant (P < 0.01) depression in the number of diabetic PMNs migrating along an fMLP gradient. In addition, a significant (P < 0.01) enhancement of diabetic PMN superoxide production was observed. Phagocytosis (P < 0.05) and killing by diabetic PMN of P. gingivalis was also impaired significantly (P < 0.01).
摘要
背景
糖尿病是一种全身性疾病，长期以来一直与牙周病风险增加和病情严重程度相关。多形核白细胞（PMN）在维持牙龈和牙周健康方面起着关键作用。在糖尿病患者中发现PMN功能降低。
目的
本研究的目的是评估15例患有慢性广泛性牙周炎的糖尿病患者的PMN功能。
材料与方法
相对于健康且匹配的对照组，评估糖尿病患者PMN的趋化性、超氧化物生成、吞噬作用以及对牙龈卟啉单胞菌的杀伤作用。
结果
这些分析显示，沿fMLP梯度迁移的糖尿病患者PMN数量显著减少（P < 0.01）。此外，观察到糖尿病患者PMN超氧化物生成显著增强（P < 0.01）。糖尿病患者PMN对牙龈卟啉单胞菌的吞噬作用（P < 0.05）和杀伤作用也显著受损（P < 0.01）。
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